NORMENT, Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
NORMENT, Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Department of Psychiatry, Ostfold Hospital Trust, Graalum, Norway.
Psychiatry Res Neuroimaging. 2021 Jan 30;307:111233. doi: 10.1016/j.pscychresns.2020.111233. Epub 2020 Dec 3.
Investigating commonalities in underlying pathology of cognitive dysfunction and negative symptoms in schizophrenia is important, as both are core features of the disorder and linked to brain structure abnormalities. We aimed to explore the relationship between cognition, negative symptoms and brain structure in schizophrenia. A total of 225 patients with Schizophrenia spectrum disorder and 283 healthy controls from the Norwegian Thematically Organized Psychosis (TOP) cohort were included in this study. Patients were categorized into four patient subgroups based on severity of negative symptoms: no-negative- (NNS), threshold-negative- (TNS), moderate-negative- (MNS), and prominent-negative (PNS) subgroups. MRI measures of brain volume, mean cortical thickness and surface area from pre-selected brain regions were tested for relationships with general cognitive ability and negative symptom subgroups. Positive associations were found between brain volume, thickness, surface area and cognition in the dorsolateral prefrontal cortex (DLPFC), orbitofrontal cortex (OFC), fusiform gyrus (FG) and the left anterior cingulate cortex (ACC), but with no differences between subgroups. In the PNS subgroup, cognition was conversely negatively associated with brain volume in the left ACC. These results indicate that patients with prominent negative symptoms have different associations between cognition and brain structure in the left ACC, which may point to abnormal neurodevelopment.
研究精神分裂症认知功能障碍和阴性症状的潜在病理学共性很重要，因为这两者都是该疾病的核心特征，并且与大脑结构异常有关。我们旨在探讨精神分裂症患者的认知、阴性症状与大脑结构之间的关系。本研究共纳入了来自挪威主题组织精神病学（TOP）队列的 225 名精神分裂症谱系障碍患者和 283 名健康对照者。根据阴性症状的严重程度，患者被分为四个亚组：无阴性症状（NNS）、轻度阴性症状（TNS）、中度阴性症状（MNS）和明显阴性症状（PNS）。对大脑体积、皮质厚度和表面积的 MRI 测量值进行了预先选择的大脑区域与一般认知能力和阴性症状亚组的关系测试。在背外侧前额叶皮质（DLPFC）、眶额皮质（OFC）、梭状回（FG）和左侧前扣带回皮质（ACC）中，发现了大脑体积、厚度、表面积与认知之间的正相关关系，但亚组之间没有差异。在 PNS 亚组中，认知与左侧 ACC 的大脑体积呈负相关。这些结果表明，有明显阴性症状的患者在左侧 ACC 中，认知与大脑结构之间的关联不同，这可能表明神经发育异常。
