精神分裂症合并强迫症患者的灰质体积和皮质厚度改变。
Altered grey matter volume and cortical thickness in patients with schizo-obsessive comorbidity.
机构信息
Neuropsychology and Applied Cognitive Neuroscience Laboratory, CAS Key Laboratory of Mental Health, Institute of Psychology, Beijing 100101, PR China; Sino-Danish College, University of Chinese Academy of Sciences, Beijing 100190, PR China; Sino-Danish Center for Education and Research, Beijing 100190, PR China; Department of Psychology, University of Chinese Academy of Sciences, Beijing, PR China.
Neuropsychology and Applied Cognitive Neuroscience Laboratory, CAS Key Laboratory of Mental Health, Institute of Psychology, Beijing 100101, PR China; Department of Psychology, School of Public Health, Southern Medical University (Guangdong Provincial Key Laboratory of Tropical Disease Research), Guangzhou, Guangdong, PR China.
出版信息
Psychiatry Res Neuroimaging. 2018 Jun 30;276:65-72. doi: 10.1016/j.pscychresns.2018.03.009. Epub 2018 Mar 28.
Recent findings suggest that schizo-obsessive comorbidity (SOC) may be a unique diagnostic entity. We examined grey matter (GM) volume and cortical thickness in 22 patients with SOC, and compared them with 21 schizophrenia (SCZ) patients, 22 obsessive-compulsive disorder (OCD) patients and 22 healthy controls (HCs). We found that patients with SOC exhibited reduced GM volume in the left thalamus, the left inferior semi-lunar lobule of the cerebellum, the bilateral medial orbitofrontal cortex (medial oFC), the medial superior frontal gyrus (medial sFG), the rectus gyrus and the anterior cingulate cortex (aCC) compared with HCs. Patients with SOC also exhibited reduced cortical thickness in the right superior temporal gyrus (sTG), the right angular gyrus, the right supplementary motor area (SMA), the right middle cingulate cortex (mCC) and the right middle occipital gyrus (mOG) compared with HCs. Together with the differences in GM volume and cortical thickness between patients with SOC and patients with only SCZ or only OCD, these findings highlight the GM changes specific to patients with SOC.
最近的研究结果表明，精神分裂症伴强迫共病（SOC）可能是一种独特的诊断实体。我们检查了 22 名 SOC 患者、21 名精神分裂症（SCZ）患者、22 名强迫症（OCD）患者和 22 名健康对照组（HCs）的灰质（GM）体积和皮质厚度。我们发现 SOC 患者与 HCs 相比，左侧丘脑、左侧小脑下半月叶、双侧内侧眶额皮质（medial oFC）、内侧额上回（medial sFG）、直回和前扣带皮质（aCC）的 GM 体积减少。SOC 患者与 HCs 相比，右侧颞上回（sTG）、右侧角回、右侧辅助运动区（SMA）、右侧中央扣带回（mCC）和右侧中枕叶（mOG）的皮质厚度也减少。与 SOC 患者和仅 SCZ 或仅 OCD 患者之间的 GM 体积和皮质厚度差异一起，这些发现强调了 SOC 患者特有的 GM 变化。
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