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中国 COVID-19 疫情期间心理障碍的流行情况:一项真实世界的横断面研究。

Prevalence of psychological disorders in the COVID-19 epidemic in China: A real world cross-sectional study.

机构信息

Department of Neurology and Psychiatry, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.

Hubei Provincial Hospital of Integrated Chinese and Western Medicine, 430015, China.

出版信息

J Affect Disord. 2021 Feb 15;281:312-320. doi: 10.1016/j.jad.2020.11.118. Epub 2020 Dec 1.

Abstract

OBJECTIVE

This study aimed to explore the prevalence of psychological disorders and associated factors at different stages of the COVID-19 epidemic in China.

METHODS

The mental health status of respondents was assessed via the Patient Health Questionnaire-9 (PHQ-9), Insomnia Severity Index (ISI) and the Generalized Anxiety Disorder 7 (GAD-7) scale.

RESULTS

5657 individuals participated in this study. History of chronic disease was a common risk factor for severe present depression (OR 2.2, 95% confidence interval [CI], 1.82-2.66, p < 0.001), anxiety (OR 2.41, 95% CI, 1.97-2.95, p < 0.001), and insomnia (OR 2.33, 95% CI, 1.83-2.95, p < 0.001) in the survey population. Female respondents had a higher risk of depression (OR 1.61, 95% CI, 1.39-1.87, p < 0.001) and anxiety (OR 1.35, 95% CI, 1.15-1.57, p < 0.001) than males. Among the medical workers, confirmed or suspected positive COVID-19 infection as associated with higher scores for depression (confirmed, OR 1.87; suspected, OR 4.13), anxiety (confirmed, OR 3.05; suspected, OR 3.07), and insomnia (confirmed, OR 3.46; suspected, OR 4.71).

LIMITATION

The cross-sectional design of present study presents inference about causality. The present psychological assessment was based on an online survey and on self-report tools, albeit using established instruments. We cannot estimate the participation rate, since we cannot know how many potential subjects received and opened the link for the survey.

CONCLUSIONS

Females, non-medical workers and those with a history of chronic diseases have had higher risks for depression, insomnia, and anxiety. Positive COVID-19 infection status was associated with higher risk of depression, insomnia, and anxiety in medical workers.

摘要

目的

本研究旨在探讨中国 COVID-19 疫情不同阶段心理障碍的患病率及相关因素。

方法

采用患者健康问卷-9(PHQ-9)、失眠严重程度指数(ISI)和广泛性焦虑症 7 项量表(GAD-7)评估受访者的心理健康状况。

结果

共有 5657 人参与了本研究。慢性病史是重度抑郁(OR 2.2,95%置信区间 [CI],1.82-2.66,p<0.001)、焦虑(OR 2.41,95% CI,1.97-2.95,p<0.001)和失眠(OR 2.33,95% CI,1.83-2.95,p<0.001)在调查人群中共同的高危因素。女性受访者患抑郁(OR 1.61,95% CI,1.39-1.87,p<0.001)和焦虑(OR 1.35,95% CI,1.15-1.57,p<0.001)的风险高于男性。在医务人员中,确诊或疑似 COVID-19 感染与抑郁(确诊,OR 1.87;疑似,OR 4.13)、焦虑(确诊,OR 3.05;疑似,OR 3.07)和失眠(确诊,OR 3.46;疑似,OR 4.71)评分较高相关。

局限性

本研究的横断面设计提出了因果关系的推断。目前的心理评估是基于在线调查和自我报告工具,尽管使用了既定的工具。我们无法估计参与率,因为我们不知道有多少潜在的对象收到并打开了调查链接。

结论

女性、非医务人员和患有慢性病的人患抑郁、失眠和焦虑的风险更高。COVID-19 阳性感染状态与医务人员抑郁、失眠和焦虑风险增加相关。

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