Department of Biochemistry and General Chemistry, Medical College of the University of Rzeszow, Rzeszów, Poland.
Department of Photomedicine and Physical Chemistry, Medical College of the University of Rzeszow, Rzeszów, Poland.
Biomed Pharmacother. 2021 Feb;134:111095. doi: 10.1016/j.biopha.2020.111095. Epub 2020 Dec 16.
Photooxidation generates reactive oxygen species (ROS) through the interaction of dyes or surfaces with light radiation of appropriate wavelength. The reaction is of wide utility and is highly effective in photodynamic therapy (PDT) of various types of cancer and skin disease. Understanding generation of singlet oxygen has contributed to the development of PDT and its subsequent use in vivo. However, this therapy has some limitations that prevent its use in the treatment of cancers located deep within the body. The limited depth of light penetration through biological tissue limits initiation of PDT action in deep tissue. Measurement of oxygen photo consumption is critical due to tumor hypoxia, and use of magnetic resonance imaging (MRI) is particularly attractive since it is non-invasive. This article presents bioluminescence (BL) and chemiluminescence (CL) phenomena based on publications from the last 20 years, and preliminary results from our lab in the use of MRI to measure oxygen concentration in water. Current work is aimed at improving the effectiveness of singlet oxygen delivery to deep tissue cancer.
光氧化通过染料或表面与适当波长的光辐射相互作用产生活性氧（ROS）。该反应用途广泛，在各种类型的癌症和皮肤病的光动力疗法（PDT）中非常有效。对单线态氧生成的理解促进了 PDT 的发展及其随后在体内的应用。然而，这种疗法存在一些限制，阻止了其在治疗位于身体深处的癌症中的应用。生物组织对光的穿透深度有限，限制了 PDT 作用在深部组织中的启动。由于肿瘤缺氧，氧气光消耗的测量至关重要，而磁共振成像（MRI）的使用特别有吸引力，因为它是非侵入性的。本文介绍了基于过去 20 年出版物的生物发光（BL）和化学发光（CL）现象，以及我们实验室在使用 MRI 测量水中氧浓度方面的初步结果。目前的工作旨在提高将单线态氧输送到深部组织癌症的有效性。
