临床5-氨基酮戊酸光动力疗法的体内单线态氧剂量测定
In-vivo singlet oxygen dosimetry of clinical 5-aminolevulinic acid photodynamic therapy.
作者信息
Laubach Hans-Joachim, Chang Sung K, Lee Seonkyung, Rizvi Imran, Zurakowski David, Davis Steven J, Taylor Charles R, Hasan Tayyaba
机构信息
Massachusetts General Hospital, Wellman Center for Photomedicine, Boston, Massachusetts 02114, USA.
出版信息
J Biomed Opt. 2008 Sep-Oct;13(5):050504. doi: 10.1117/1.2981813.
Abstract
Photodynamic therapy (PDT) is a viable treatment option for a wide range of applications, including oncology, dermatology, and ophthalmology. Singlet oxygen is believed to play a key role in the efficacy of PDT, and on-line monitoring of singlet oxygen during PDT could provide a methodology to establish and customize the treatment dose clinically. This work is the first report of monitoring singlet oxygen luminescence in vivo in human subjects during PDT, demonstrating the correlation of singlet oxygen levels during PDT with the post-PDT photobiological response.
摘要
光动力疗法（PDT）是一种适用于广泛应用领域的可行治疗选择，包括肿瘤学、皮肤病学和眼科。单线态氧被认为在PDT的疗效中起关键作用，并且在PDT过程中对单线态氧进行在线监测可为临床建立和定制治疗剂量提供一种方法。这项工作是关于在PDT过程中对人体受试者体内单线态氧发光进行监测的首次报告，证明了PDT过程中单线态氧水平与PDT后光生物学反应之间的相关性。
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本文引用的文献
1
Pulsed diode laser-based monitor for singlet molecular oxygen.
J Biomed Opt. 2008 May-Jun;13(3):034010. doi: 10.1117/1.2927465.
2
Monitoring of singlet oxygen is useful for predicting the photodynamic effects in the treatment for experimental glioma.
Clin Cancer Res. 2006 Dec 1;12(23):7132-9. doi: 10.1158/1078-0432.CCR-06-0786.
3
Topical application of 5-aminolaevulinic acid, methyl 5-aminolaevulinate and hexyl 5-aminolaevulinate on normal human skin.
Br J Dermatol. 2006 Oct;155(4):791-9. doi: 10.1111/j.1365-2133.2006.07484.x.
4
Photodynamic therapy in dermatology.
Eur J Dermatol. 2006 Jul-Aug;16(4):340-8.
5
Histamine is released following aminolevulinic acid-photodynamic therapy of human skin and mediates an aminolevulinic acid dose-related immediate inflammatory response.
J Invest Dermatol. 2006 Oct;126(10):2296-301. doi: 10.1038/sj.jid.5700449. Epub 2006 Jun 22.
6
Singlet oxygen luminescence as an in vivo photodynamic therapy dose metric: validation in normal mouse skin with topical amino-levulinic acid.
Br J Cancer. 2005 Jan 31;92(2):298-304. doi: 10.1038/sj.bjc.6602331.
7
Photodynamic therapy of actinic keratosis at varying fluence rates: assessment of photobleaching, pain and primary clinical outcome.
Br J Dermatol. 2004 Dec;151(6):1204-12. doi: 10.1111/j.1365-2133.2004.06211.x.
8
Changes in function and morphology of normal human skin: evaluation using optical coherence tomography.
Br J Dermatol. 2004 Feb;150(2):220-5. doi: 10.1111/j.1365-2133.2004.05810.x.
9
Photodynamic therapy of actinic keratosis with topical 5-aminolevulinic acid. A pilot dose-ranging study.
Arch Dermatol. 1997 Jun;133(6):727-32.
10
Photodynamic treatment of skin malignancies with aminolevulinic acid. Emphasis on anatomical observations and in vivo erythema visual assessment.
Dermatol Surg. 1996 Nov;22(11):929-34.
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