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本文引用的文献

1
Pulsed diode laser-based monitor for singlet molecular oxygen.基于脉冲二极管激光器的单线态分子氧监测仪。
J Biomed Opt. 2008 May-Jun;13(3):034010. doi: 10.1117/1.2927465.
2
Monitoring of singlet oxygen is useful for predicting the photodynamic effects in the treatment for experimental glioma.单线态氧的监测对于预测实验性胶质瘤治疗中的光动力效应很有用。
Clin Cancer Res. 2006 Dec 1;12(23):7132-9. doi: 10.1158/1078-0432.CCR-06-0786.
3
Topical application of 5-aminolaevulinic acid, methyl 5-aminolaevulinate and hexyl 5-aminolaevulinate on normal human skin.5-氨基乙酰丙酸、5-氨基乙酰丙酸甲酯和5-氨基乙酰丙酸己酯在正常人体皮肤上的局部应用。
Br J Dermatol. 2006 Oct;155(4):791-9. doi: 10.1111/j.1365-2133.2006.07484.x.
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Photodynamic therapy in dermatology.皮肤科中的光动力疗法。
Eur J Dermatol. 2006 Jul-Aug;16(4):340-8.
5
Histamine is released following aminolevulinic acid-photodynamic therapy of human skin and mediates an aminolevulinic acid dose-related immediate inflammatory response.在人皮肤的氨基乙酰丙酸光动力疗法后，组胺被释放，并介导一种与氨基乙酰丙酸剂量相关的即时炎症反应。
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6
Singlet oxygen luminescence as an in vivo photodynamic therapy dose metric: validation in normal mouse skin with topical amino-levulinic acid.单线态氧发光作为一种体内光动力治疗剂量指标：在正常小鼠皮肤中使用局部氨基乙酰丙酸的验证
Br J Cancer. 2005 Jan 31;92(2):298-304. doi: 10.1038/sj.bjc.6602331.
7
Photodynamic therapy of actinic keratosis at varying fluence rates: assessment of photobleaching, pain and primary clinical outcome.不同光通量率下光动力疗法治疗光化性角化病：光漂白、疼痛及主要临床结果评估
Br J Dermatol. 2004 Dec;151(6):1204-12. doi: 10.1111/j.1365-2133.2004.06211.x.
8
Changes in function and morphology of normal human skin: evaluation using optical coherence tomography.正常人体皮肤的功能和形态变化：使用光学相干断层扫描进行评估
Br J Dermatol. 2004 Feb;150(2):220-5. doi: 10.1111/j.1365-2133.2004.05810.x.
9
Photodynamic therapy of actinic keratosis with topical 5-aminolevulinic acid. A pilot dose-ranging study.外用5-氨基酮戊酸光动力疗法治疗光化性角化病。一项剂量范围探索性研究。
Arch Dermatol. 1997 Jun;133(6):727-32.
10
Photodynamic treatment of skin malignancies with aminolevulinic acid. Emphasis on anatomical observations and in vivo erythema visual assessment.用氨基乙酰丙酸对皮肤恶性肿瘤进行光动力治疗。重点在于解剖学观察和体内红斑视觉评估。
Dermatol Surg. 1996 Nov;22(11):929-34.

临床5-氨基酮戊酸光动力疗法的体内单线态氧剂量测定

In-vivo singlet oxygen dosimetry of clinical 5-aminolevulinic acid photodynamic therapy.

作者信息

Laubach Hans-Joachim, Chang Sung K, Lee Seonkyung, Rizvi Imran, Zurakowski David, Davis Steven J, Taylor Charles R, Hasan Tayyaba

机构信息

Massachusetts General Hospital, Wellman Center for Photomedicine, Boston, Massachusetts 02114, USA.

出版信息

J Biomed Opt. 2008 Sep-Oct;13(5):050504. doi: 10.1117/1.2981813.

DOI:10.1117/1.2981813
PMID:19021376
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2994192/
Abstract

Photodynamic therapy (PDT) is a viable treatment option for a wide range of applications, including oncology, dermatology, and ophthalmology. Singlet oxygen is believed to play a key role in the efficacy of PDT, and on-line monitoring of singlet oxygen during PDT could provide a methodology to establish and customize the treatment dose clinically. This work is the first report of monitoring singlet oxygen luminescence in vivo in human subjects during PDT, demonstrating the correlation of singlet oxygen levels during PDT with the post-PDT photobiological response.

摘要

光动力疗法（PDT）是一种适用于广泛应用领域的可行治疗选择，包括肿瘤学、皮肤病学和眼科。单线态氧被认为在PDT的疗效中起关键作用，并且在PDT过程中对单线态氧进行在线监测可为临床建立和定制治疗剂量提供一种方法。这项工作是关于在PDT过程中对人体受试者体内单线态氧发光进行监测的首次报告，证明了PDT过程中单线态氧水平与PDT后光生物学反应之间的相关性。