临床5-氨基酮戊酸光动力疗法的体内单线态氧剂量测定
In-vivo singlet oxygen dosimetry of clinical 5-aminolevulinic acid photodynamic therapy.
作者信息
Laubach Hans-Joachim, Chang Sung K, Lee Seonkyung, Rizvi Imran, Zurakowski David, Davis Steven J, Taylor Charles R, Hasan Tayyaba
机构信息
Massachusetts General Hospital, Wellman Center for Photomedicine, Boston, Massachusetts 02114, USA.
出版信息
J Biomed Opt. 2008 Sep-Oct;13(5):050504. doi: 10.1117/1.2981813.
Abstract
Photodynamic therapy (PDT) is a viable treatment option for a wide range of applications, including oncology, dermatology, and ophthalmology. Singlet oxygen is believed to play a key role in the efficacy of PDT, and on-line monitoring of singlet oxygen during PDT could provide a methodology to establish and customize the treatment dose clinically. This work is the first report of monitoring singlet oxygen luminescence in vivo in human subjects during PDT, demonstrating the correlation of singlet oxygen levels during PDT with the post-PDT photobiological response.
摘要
光动力疗法（PDT）是一种适用于广泛应用领域的可行治疗选择，包括肿瘤学、皮肤病学和眼科。单线态氧被认为在PDT的疗效中起关键作用，并且在PDT过程中对单线态氧进行在线监测可为临床建立和定制治疗剂量提供一种方法。这项工作是关于在PDT过程中对人体受试者体内单线态氧发光进行监测的首次报告，证明了PDT过程中单线态氧水平与PDT后光生物学反应之间的相关性。
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