Ghent University, Department of Plant Biotechnology and Bioinformatics, Ghent, Belgium; VIB Center for Plant Systems Biology, Ghent, Belgium.
Instituto de Biología Molecular y Celular de Plantas (IBMCP-UPV-CSIC), Valencia, Spain.
Trends Biotechnol. 2021 Sep;39(9):901-913. doi: 10.1016/j.tibtech.2020.11.012. Epub 2020 Dec 17.
Molecular farming intends to use crop plants as biofactories for high value-added compounds following application of a wide range of biotechnological tools. In particular, the conversion of nonfood crops into efficient biofactories is expected to be a strong asset in the development of a sustainable bioeconomy. The 'nonfood' status combined with the high metabolic versatility and the capacity of high-yield cultivation highlight the plant genus Nicotiana as one of the most appropriate 'chassis' for molecular farming. Nicotiana species are a rich source of valuable industrial, active pharmaceutical ingredients and nutritional compounds, synthesized from highly complex biosynthetic networks. Here, we review and discuss approaches currently used to design enriched Nicotiana species for molecular farming using new plant breeding techniques (NPBTs).
分子农业旨在应用广泛的生物技术工具，将农作物作为生物工厂来生产高附加值化合物。特别是，将非食用作物转化为高效生物工厂，预计将成为可持续生物经济发展的有力资产。“非食用”的地位，加上高度的代谢多功能性和高产栽培的能力，突出了烟草属植物是分子农业最适合的“底盘”之一。烟草属植物是有价值的工业、活性药物成分和营养化合物的丰富来源，这些化合物是由高度复杂的生物合成网络合成的。在这里，我们综述并讨论了目前使用的利用新的植物育种技术（NPBTs）来设计富含烟草属植物的方法，以用于分子农业。
