Chen Tiantian, Ma Yanfei, Qi Jiyan
Shaanxi Key Laboratory of Qinling Ecological Intelligent Monitoring and Protection, School of Ecology and Environment, Northwestern Polytechnical University, Xi'an 710129, China.
Shenzhen Research Institute, Northwestern Polytechnical University, Shenzhen 518057, China.
Int J Mol Sci. 2025 Jul 21;26(14):7008. doi: 10.3390/ijms26147008.
Trichomes-microscopic appendages on the plant epidermis-play vital roles as both protective barriers and specialized biosynthetic factories. Acting as the first line of defense against environmental stressors, they also produce a wide range of pharmaceutically valuable secondary metabolites. This mini-review highlights recent advances in understanding the development, structure, and function of trichomes, with a focus on glandular secretory trichomes (GSTs) in key species such as and . We explore how insights from these systems are driving innovation in plant synthetic biology, including modular genetic engineering and metabolic channeling strategies. These breakthroughs are paving the way for scalable, plant-based platforms to produce high-value compounds. By integrating molecular mechanisms with emerging technologies, this review outlines a forward-looking framework for leveraging trichomes in sustainable agriculture, natural product discovery, and next-generation biomanufacturing.
植物表皮上的微小附属物——毛状体，作为保护屏障和特殊的生物合成工厂发挥着至关重要的作用。作为抵御环境压力源的第一道防线，它们还产生多种具有药学价值的次生代谢产物。本综述着重介绍了在理解毛状体的发育、结构和功能方面的最新进展，重点关注如[具体物种1]和[具体物种2]等关键物种中的腺毛状体（GSTs）。我们探讨了这些系统的见解如何推动植物合成生物学的创新，包括模块化基因工程和代谢通道策略。这些突破为生产高价值化合物的可扩展植物基平台铺平了道路。通过将分子机制与新兴技术相结合，本综述概述了一个前瞻性框架，用于在可持续农业、天然产物发现和下一代生物制造中利用毛状体。
