巴博勒省过敏性患者鼻息肉的流行病学和免疫学研究：横断面研究。

Epidemiological and immunological study of nasal polyposis among allergic patients in Babylon province: Cross-sectional study.

机构信息

Department of Otolaryngology, College of Medicine, Kufa University, Najaf, Iraq.

Department of Medical Microbiology, College of Medicine, Kufa University, Najaf, Iraq.

出版信息

J Pak Med Assoc. 2020 Nov;70(11):1975-1978. doi: 10.5455/JPMA.64913.

DOI:10.5455/JPMA.64913

PMID:33341843

Abstract

OBJECTIVE

To determine the prevalence of nasal polyposis among allergic patients, and to investigate the impact of polyposis on allergic inflammatory markers.

METHODS

The cross-sectional study was conducted from January 2018 to January 2019 at the Asthma and Allergy Centre, Babylon, Iraq, and comprised patients aged 15-71 years with allergic asthma and or allergic rhinitis. The patients were divided into two groups; A with nasal polyposis, and B without nasal polyposis. Other than demographical data, total serum immuglobulin E, and blood eosinophil percentage were collected. Data was analysed using SPSS 22.

RESULTS

Of the 240 patients, 81(33.8%) were in group A, and 159(66.2%) were in group B. The overall mean age of the sample was 35.9±13.8 years. The overall mean immunoglobulin E level was 221±141 and the mean peripheral eosinophil percentage was 4±1.68. Prevalence of nasal polyposis increased with age (p<0.05), but was not affected by gender or residency (p>0.05). The markers increased significantly in the presence of polyposis in patients with respiratory allergy (p<0.05).

CONCLUSIONS

Nasal polyposis was found to be highly prevalent in patients with respiratory allergy and the combined presence of these two diseases caused additional increment in allergic markers.

摘要

目的

确定变应性患者中鼻息肉的患病率，并研究鼻息肉对变应性炎症标志物的影响。

方法

本横断面研究于 2018 年 1 月至 2019 年 1 月在伊拉克巴比伦的哮喘和过敏中心进行，纳入年龄在 15-71 岁之间的过敏性哮喘和/或过敏性鼻炎患者。将患者分为两组；A 组有鼻息肉，B 组无鼻息肉。除了人口统计学数据外，还收集了总血清免疫球蛋白 E 和血嗜酸性粒细胞百分比。使用 SPSS 22 进行数据分析。

结果

在 240 名患者中，81 名（33.8%）在 A 组，159 名（66.2%）在 B 组。样本的总体平均年龄为 35.9±13.8 岁。总体平均免疫球蛋白 E 水平为 221±141，外周血嗜酸性粒细胞百分比平均为 4±1.68。鼻息肉的患病率随年龄增长而增加（p<0.05），但不受性别或居住地影响（p>0.05）。在呼吸道过敏患者中，存在鼻息肉时标志物显著增加（p<0.05）。