Ali Ghazanfar, Riaz-Ul-Hassan Sardar, Shah Muhammad Ali, Javid Muhammad Qudir, Khan Abdul Rehman, Shakir Lubna
Department of Biotechnology, The University of Azad Jammu and Kashmir, Muzaffarabad, Pakistan.
Department of Pharmacology, Abbas Institute of Medical Sciences AIMS Muzaffarabad, Azad Jammu and Kashmir, Pakistan.
J Pak Med Assoc. 2020 Nov;70(11):2039-2042. doi: 10.5455/JPMA.10831.
The present research study was done to determine the correlation between antibiotic susceptibility and drug prescription patterns in empirical treatment of uropathogenic Escherichia coli (E. coli) in two hospitals of district Muzaffarabad, Azad Kashmir, Pakistan. One hundred uropathogenic E. coli clinical isolates were collected from UTI patients who attended the Combined Military Hospital (CMH) and Abbas Institute of Medical Sciences (AIMS), district Muzaffarabad, AJK. All isolates were subjected to antibiotic susceptibility against seven commonly prescribed antibiotics by Kirby-Bauer disk diffusion method. However, all the E. coli isolates were susceptible to Imipenem. Eight percent and 10% of isolates from CMH and AIMS were found to be resistant against Nitrofurantoin drug respectively. Similarly, 94% and 74% isolates from CMH and 60% and 64% isolates from AIMS were found to be resistant against Co-trimoxazole and Coamoxiclave, respectively. Pipemedic acid resistance was also detected in 76% and 60% isolates from AIMS and CMH, respectively. Ciprofloxacin resistance was also observed in 54% and 36% isolates from AIMS and CMH, respectively. The finding of the study revealed that both hospitals have different drug susceptibility pattern against uropathogenic E. coli, which may be associated with patterns of drug prescription in empirical treatment of urinary tract infections. There is a vital need for appropriate development of hospital-specific antibiograms to determine appropriate empiric therapy of urinary tract infections.
本研究旨在确定巴基斯坦阿扎德克什米尔穆扎法拉巴德地区两家医院在对尿路致病性大肠杆菌（E. coli）进行经验性治疗时，抗生素敏感性与药物处方模式之间的相关性。从穆扎法拉巴德地区联合军事医院（CMH）和阿巴斯医学科学研究所（AIMS）就诊的尿路感染（UTI）患者中收集了100株尿路致病性大肠杆菌临床分离株。通过 Kirby-Bauer 纸片扩散法对所有分离株进行了七种常用抗生素的药敏试验。然而，所有大肠杆菌分离株对亚胺培南均敏感。分别发现CMH和AIMS分离株中有8%和10%对呋喃妥因耐药。同样，分别发现CMH分离株中有94%和74%、AIMS分离株中有60%和64%对复方新诺明和阿莫西林克拉维酸耐药。在AIMS和CMH分离株中，分别有76%和60%检测到对吡哌酸耐药。在AIMS和CMH分离株中，分别有54%和36%观察到对环丙沙星耐药。研究结果表明，两家医院对尿路致病性大肠杆菌的药敏模式不同，这可能与尿路感染经验性治疗中的药物处方模式有关。迫切需要制定适合医院的抗菌谱，以确定尿路感染的适当经验性治疗方案。
