Institute of Environment and Sustainable Development in Agriculture, Chinese Academy of Agricultural Sciences, Beijing, China.
Pest Manag Sci. 2021 Apr;77(4):2078-2086. doi: 10.1002/ps.6236. Epub 2021 Jan 5.
Safe and efficient nanopesticides for pest control have attracted attention because of their ability to enhance target efficiency and reduce undesirable side effects. Nanoformulations have a significant role in solving the problem of water solubility for insoluble drugs. However, there are few studies on the physicochemical properties and biological activities of pesticides of different particle sizes and remains unclear how these key physicochemical properties are affected by particle size. In this study, a series of glucose-loaded lambda-cyhalothrin nanoparticles (LCNs) with a tunable size were developed via shearing emulsification and carrier loading in order to evaluate insecticidal action.
The mean particle sizes of the LCNs were 50.6, 115.2 and 221 nm. The wettability, dispersibility and stability of nanoparticles were particle size-dependent, and were mainly determined by particle size and the uniformity of distribution. Furthermore, the insecticidal activity of LCNs was inversely proportional to the particle size.
This study not only provides a facile technology for the preparation of nanopesticides with a tunable particle size, but also clarifies the effect of particle size on the performance of pesticides. © 2020 Society of Chemical Industry.
安全高效的纳米杀虫剂因其能够提高靶标效率和降低不良副作用而受到关注。纳米制剂在解决难溶性药物的水溶性问题方面发挥着重要作用。然而，对于不同粒径的农药的物理化学性质和生物活性的研究较少，粒径如何影响这些关键物理化学性质尚不清楚。在本研究中，通过剪切乳化和载体加载开发了一系列可调节粒径的载有葡萄糖的氯氰菊酯纳米颗粒（LCNs），以评估杀虫作用。
LCNs 的平均粒径分别为 50.6nm、115.2nm 和 221nm。纳米颗粒的润湿性、分散性和稳定性与粒径有关，主要由粒径和分布均匀性决定。此外，LCNs 的杀虫活性与粒径成反比。
本研究不仅为制备具有可调粒径的纳米农药提供了一种简便的技术，而且阐明了粒径对农药性能的影响。 © 2020 英国化学学会。
