Department of Surgery, Division of Upper GI and General Surgery, Keck School of Medicine, 12223University of Southern California, Los Angeles, CA, USA.
Department of Medicine, 22494Cedars Sinai Medical Center, Los Angeles, CA, USA.
Am Surg. 2021 Aug;87(8):1287-1291. doi: 10.1177/0003134820979781. Epub 2020 Dec 19.
Laparoscopic sleeve gastrectomy (LSG) has recently been considered for the surgical management of refractory gastroparesis. Our study aims to determine the efficacy of LSG as a new treatment modality for gastroparesis.
A multi-surgeon single institution retrospective chart review of patients who underwent LSG for refractory gastroparesis from September 2016-December 2017. Pre- and postoperative Patient Assessment of Upper Gastrointestinal Disorders-Symptoms Severity Index and/or Gastroparesis Cardinal Symptom Index (GCSI) questionnaires were reviewed. A telephone survey was conducted. Statistical analysis consisted of two-sample t test and utilized SAS v9.4. A -value <.05 was considered significant.
There were 10 patients included and 80% were women with an average age of 43 years (24-63). Mean Body Mass Index was 24.5 (16.8-39.6), and median gastric emptying at 4 hours was 50% (30-85). Etiology of gastroparesis was 50% idiopathic, 40% diabetic, and 10% postsurgical. 80% of patients had previously undergone gastric electrical stimulator implantation, 20% pyloric botox injections, and 1 patient jejunostomy tube placement. One patient required conversion from laparoscopic to open secondary to adhesions. Median length of stay was 5 days (2-13), and median follow-up was 13.3 months. 90% of patients were tolerating a regular diet at longest follow-up with significant improvement in self-reported symptoms. GCSI scores were 33.6 preoperatively and 14.9 postoperatively ( = .01).
Our study adds to the literature examining the role of LSG in the treatment of gastroparesis. LSG has favorable outcomes at short-term follow-up for patients with refractory gastroparesis.
腹腔镜袖状胃切除术(LSG)最近被认为是治疗难治性胃轻瘫的手术方法。我们的研究旨在确定 LSG 作为胃轻瘫新的治疗方法的疗效。
对 2016 年 9 月至 2017 年 12 月期间因难治性胃轻瘫而行 LSG 的多外科医生单机构回顾性图表进行回顾。审查了术前和术后患者上消化道疾病症状严重程度指数(Patient Assessment of Upper Gastrointestinal Disorders-Symptoms Severity Index,PASS-SI)和/或胃轻瘫主要症状指数(Gastroparesis Cardinal Symptom Index,GCSI)问卷。进行了电话调查。统计分析包括两样本 t 检验,并使用 SAS v9.4 进行分析。a 值<0.05 被认为具有统计学意义。
共纳入 10 例患者,其中 80%为女性,平均年龄为 43 岁(24-63 岁)。平均体重指数为 24.5(16.8-39.6),4 小时胃排空中位数为 50%(30-85)。胃轻瘫的病因 50%为特发性,40%为糖尿病,10%为手术后。80%的患者曾接受过胃电刺激器植入,20%接受过幽门肉毒杆菌注射,1 例患者接受过空肠造口管放置。1 例患者因粘连需转为开腹手术。中位住院时间为 5 天(2-13 天),中位随访时间为 13.3 个月。在最长随访时,90%的患者能耐受常规饮食,自述症状有明显改善。GCSI 评分术前为 33.6,术后为 14.9(=0.01)。
我们的研究增加了检查 LSG 在治疗胃轻瘫中的作用的文献。LSG 在短期随访中对难治性胃轻瘫患者具有良好的效果。