General Dental Practitioner, Hamadan University of Medical Science, Hamadan,Iran.
Medical School, Department of Immunology and Hematology , Hamadan University of Medical Sciences, Hamadan,Iran.
Infect Disord Drug Targets. 2021;21(7):e160921189262. doi: 10.2174/1871526520666201218154530.
Helicobacter pylori infection is identified as a major cause of stomach ulcers, chronic inflammation and gastric cancer in hemodialysis patients. Dialysis also leads to changes in the composition and flow of saliva.
The aim of this study was to investigate the salivary Helicobacter pylori infection, Calcium, Urea, pH and flow rate in hemodialysis patients in comparison to the healthy control group.
In this study 48 hemodialysis patients and 48 healthy subjects were compared. The prevalence of Helicobacter pylori infection was determined by PCR method. Calcium, Urea, pH, salivary flow and gastrointestinal complications in both groups were measured and compared.
Prevalence of Helicobacter pylori was 12.48 (25.0%) in the study group and 2.48 (4.2%) in the controls (P=0.000). Urea, calcium and pH were significantly higher in the patient group. The mean salivary flow rate decreased significantly in the patient group. 58.3% of patients group had gastrointestinal complications.
Oral cavity as an important external source of Helicobacter pylori may play an important role in gastrointestinal problems of hemodialysis patients. Helicobacter pylori, Urea, calcium and pH were significantly higher in the patient group. Chronic renal failure can increase pH, urea and calcium in saliva and decrease salivary flow rate.
幽门螺杆菌感染被认为是导致血液透析患者胃溃疡、慢性炎症和胃癌的主要原因。透析还会导致唾液成分和流量发生变化。
本研究旨在调查血液透析患者的唾液幽门螺杆菌感染情况，并与健康对照组进行比较。
本研究比较了 48 例血液透析患者和 48 例健康受试者。采用 PCR 法检测幽门螺杆菌感染。测量并比较两组的钙、尿素、pH 值、唾液流量和胃肠道并发症。
研究组幽门螺杆菌的患病率为 12.48%（25.0%），对照组为 2.48%（4.2%）（P=0.000）。患者组的尿素、钙和 pH 值明显更高。患者组的平均唾液流量明显下降。58.3%的患者组有胃肠道并发症。
口腔作为幽门螺杆菌的一个重要外部来源，可能在血液透析患者的胃肠道问题中发挥重要作用。患者组的幽门螺杆菌、尿素、钙和 pH 值明显更高。慢性肾衰竭会增加唾液中的 pH 值、尿素和钙，并降低唾液流量。
