Radiation Oncology Research Center, Cancer Institute, Tehran University of Medical Science, Tehran, Iran.
Department of Medical Physics, Tehran University of Medical Sciences, Tehran, Iran.
J Cancer Res Ther. 2020 Oct-Dec;16(6):1203-1209. doi: 10.4103/jcrt.JCRT_180_20.
In recent times, research on the use of ultrahigh-dose rates delivered in super-fast times in cancer treatment has been garnering interest. This has brought about the term "FLASH" radiotherapy (RT). Thus, in the present study, we systematically review these recent studies on FLASH RT with regard to its efficacy and safety. The reporting of this systematic review was done in line with the statement of Preferred Reporting Items for Systematic reviews and Meta-Analyses. Electronic search of the databases such as PubMed, Scopus, and Embase was conducted to retrieve relevant studies investigating the FLASH effect. From an initial search of 216 potential articles, 16 articles (in vivo, in vitro , and clinical studies) were finally included in this systematic review. Results showed that FLASH RT dose rates had protective effects on normal tissues in addition to antitumor effect. Although still in its early research stages, FLASH RT has the potential to rival present RT regimens in terms of safety and antitumor effect. However, further studies are needed to address the aspects such as optimal dose rate, effect on deep tumors, tumor recurrence, longer follow-up time, and mechanism of action.
近年来，人们对在癌症治疗中超高剂量率的超快传输方式的研究产生了兴趣。这就引出了“FLASH”放疗（RT）这个术语。因此，在本研究中，我们系统地回顾了这些关于 FLASH RT 的近期研究，评估其疗效和安全性。本系统评价的报告符合系统评价和荟萃分析的首选报告项目声明。通过对 PubMed、Scopus 和 Embase 等数据库进行电子检索，检索了研究 FLASH 效应的相关研究。从最初搜索到的 216 篇潜在文章中，最终有 16 篇（体内、体外和临床研究）被纳入本系统评价。结果表明，FLASH RT 剂量率除了具有抗肿瘤作用外，对正常组织还有保护作用。尽管仍处于早期研究阶段，但 FLASH RT 在安全性和抗肿瘤效果方面有可能与目前的 RT 方案相媲美。然而，仍需要进一步的研究来解决最佳剂量率、对深部肿瘤的影响、肿瘤复发、更长的随访时间以及作用机制等方面的问题。
