University of Health Sciences, Erenkoy Mental Health and Neurological Disorders Research and Training Hospital, Neurology Department, Istanbul-, Turkey.
Bahcesehir University Medical Faculty, Neurology Department, Istanbul -, Turkey.
Neurol India. 2020 Nov-Dec;68(6):1469-1471. doi: 10.4103/0028-3886.304071.
Drug-induced parkinsonism is the second common movement disorder after Parkinson's disease. It occurs due to the use of not only neuroleptics but also some other medications as pregabalin. Pregabalin is an antiepileptic drug and a structural analog of gamma-aminobutyric acid (GABA), and its use decreases the release of several neurotransmitters. In this case report, we present a 53-year-old female patient with the signs of parkinsonism following pregabalin treatment. Drug-induced parkinsonism was diagnosed based on the clinical features, investigations, and resolution of the complaints. The symptoms relieved after the treatment stopped at a follow-up of 10 days. Due to the rare report of pregabalin-induced parkinsonism, we aim to enhance clinicians' awareness of pregabalin's probable side effects.
药物性帕金森病是仅次于帕金森病的第二大常见运动障碍。它不仅由于使用神经阻滞剂，还由于使用普瑞巴林等其他一些药物而引起。普瑞巴林是一种抗癫痫药物和γ-氨基丁酸（GABA）的结构类似物，其使用会减少几种神经递质的释放。在本病例报告中，我们介绍了一位 53 岁女性患者，在使用普瑞巴林治疗后出现帕金森病的迹象。药物性帕金森病的诊断基于临床特征、检查和症状的缓解。在随访 10 天后，停止治疗后症状缓解。由于普瑞巴林引起的帕金森病罕见报告，我们旨在提高临床医生对普瑞巴林可能的副作用的认识。
