Mlole Angela T, Yahaya James J, Othieno Emmanuel, Kalungi Sam, Okwi Andrew L
Department of Pathology, Makerere College of Health Sciences (MaKCHS), Makerere University, Kampala, Uganda.
Department of Biomedical Science, College of Health Science (CHS), The University of Dodoma, Dodoma, Tanzania.
Int J Womens Health. 2020 Nov 27;12:1109-1123. doi: 10.2147/IJWH.S270082. eCollection 2020.
The expression of estrogen and progesterone receptors (ER and PR) and human epidermal growth factor receptor-2 (HER2) has been reported to have an invaluable prognostic role. The aim of this study was to determine the expression of ER, PR and HER2 in women with breast cancer (BC) in Kampala, Uganda.
Expression of ER, PR and HER2 was determined immunohistochemically. Logistic regression was performed to determine the effect of the independent factors in predicting the risk of not expressing the breast markers. A two-tailed p<0.05 was regarded to be statistically significant.
ER, PR and HER2 were expressed in 53.4%, 46.6% and 18.5%, respectively. ER and PR co-expression was present in 42.7% and 37.9% patients had triple negative breast cancer (TNBC). Age was an independent predictor of expression of ER (AOR = 0.18, 95% CI = 0.062-0.541, p = 0.002) and PR (AOR = 0.35, 95% CI = 0.129-0.968, p = 0.043).
The majority of patients in this study had less than 50 years with high tumour grade. Interestingly, most of them had high expression of HER2 with TNBC which are molecular subtypes of BC with poor prognosis. Age was an independent predictor of expression of both ER and PR.
据报道，雌激素和孕激素受体（ER和PR）以及人表皮生长因子受体2（HER2）的表达具有重要的预后作用。本研究的目的是确定乌干达坎帕拉乳腺癌（BC）女性中ER、PR和HER2的表达情况。
采用免疫组织化学法检测ER、PR和HER2的表达。进行逻辑回归分析以确定独立因素对预测乳腺标志物不表达风险的影响。双侧p<0.05被认为具有统计学意义。
ER、PR和HER2的表达率分别为53.4%、46.6%和18.5%。ER和PR共表达率为42.7%，37.9%的患者为三阴性乳腺癌（TNBC）。年龄是ER表达（比值比[AOR]=0.18，95%置信区间[CI]=0.062-0.541，p=0.002）和PR表达（AOR=0.35，95%CI=0.129-0.968，p=0.043）的独立预测因素。
本研究中的大多数患者年龄小于50岁，肿瘤分级高。有趣的是，其中大多数HER2表达高且为TNBC，这是BC的分子亚型，预后较差。年龄是ER和PR表达的独立预测因素。
