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难治性精神分裂症

Treatment-Resistant Schizophrenia.

作者信息

Buckley Peter F

机构信息

McGlothlin Medical Education Center, Virginia Commonwealth University School of Medicine, Richmond.

出版信息

Focus (Am Psychiatr Publ). 2020 Oct;18(4):364-367. doi: 10.1176/appi.focus.20200025. Epub 2020 Nov 5.

DOI:10.1176/appi.focus.20200025
PMID:33343247
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7725152/
Abstract

Although, gratifyingly, research on the treatment of schizophrenia has increasingly focused on first-episode and prodromal patient populations, it is still recognized that many patients with more chronic illnesses exhibit a suboptimal response to treatments. This suboptimal response with continuation of symptoms is represented in the term (TRS). This article addresses contemporary definitions as well as updated guidelines for patients with TRS.

摘要

尽管令人欣慰的是，关于精神分裂症治疗的研究越来越多地聚焦于首发和前驱期患者群体，但人们仍认识到，许多患有更慢性疾病的患者对治疗的反应并不理想。这种症状持续存在的不理想反应体现在“难治性精神分裂症”（TRS）这一术语中。本文探讨了TRS患者的当代定义以及更新后的指南。

相似文献

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Treatment-Resistant Schizophrenia.难治性精神分裂症
Focus (Am Psychiatr Publ). 2020 Oct;18(4):364-367. doi: 10.1176/appi.focus.20200025. Epub 2020 Nov 5.
2
First-episode psychosis in treatment-resistant schizophrenia: a cross-sectional study of a long-term follow-up cohort.首发精神分裂症患者的治疗抵抗：一项长期随访队列的横断面研究。
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The Group of Treatment Resistant Schizophrenias. Heterogeneity in Treatment Resistant Schizophrenia (TRS).难治性精神分裂症组。难治性精神分裂症（TRS）的异质性。
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Predictors of Treatment-Resistant and Clozapine-Resistant Schizophrenia: A 12-Year Follow-up Study of First-Episode Schizophrenia-Spectrum Disorders.预测治疗抵抗和氯氮平抵抗精神分裂症：首发精神分裂症谱系障碍的 12 年随访研究。
Schizophr Bull. 2021 Mar 16;47(2):485-494. doi: 10.1093/schbul/sbaa145.
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Rates of treatment-resistant schizophrenia from first-episode cohorts: systematic review and meta-analysis.首发队列中难治性精神分裂症的发生率：系统评价与荟萃分析。
Br J Psychiatry. 2022 Mar;220(3):115-120. doi: 10.1192/bjp.2021.61.
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Early intervention for psychosis.精神病的早期干预
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引用本文的文献

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The Challenge of Managing Refractory Psychosis Amid Multiple Medication Side Effects: A Case Report and Review of the Literature.在多种药物副作用情况下管理难治性精神病的挑战：一例病例报告及文献综述
Cureus. 2023 Dec 6;15(12):e50063. doi: 10.7759/cureus.50063. eCollection 2023 Dec.
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Second to none: rationale, timing, and clinical management of clozapine use in schizophrenia.首屈一指：氯氮平用于精神分裂症的基本原理、时机及临床管理
Ther Adv Psychopharmacol. 2023 Mar 25;13:20451253231158152. doi: 10.1177/20451253231158152. eCollection 2023.
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A Guideline and Checklist for Initiating and Managing Clozapine Treatment in Patients with Treatment-Resistant Schizophrenia.治疗抵抗性精神分裂症患者氯氮平治疗启动和管理的指南和检查表。
CNS Drugs. 2022 Jul;36(7):659-679. doi: 10.1007/s40263-022-00932-2. Epub 2022 Jun 27.

本文引用的文献

1
The American Psychiatric Association Practice Guideline for the Treatment of Patients With Schizophrenia.美国精神病学协会《精神分裂症患者治疗实践指南》。
Focus (Am Psychiatr Publ). 2020 Oct;18(4):493-497. doi: 10.1176/appi.focus.18402. Epub 2020 Nov 5.
2
Clozapine Combination and Augmentation Strategies in Patients With Schizophrenia -Recommendations From an International Expert Survey Among the Treatment Response and Resistance in Psychosis (TRRIP) Working Group.氯氮平联合治疗与增效策略在精神分裂症患者中的应用——精神病治疗反应和抵抗（TRRIP）工作组的国际专家调查建议。
Schizophr Bull. 2020 Dec 1;46(6):1459-1470. doi: 10.1093/schbul/sbaa060.
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A Rational Use of Clozapine Based on Adverse Drug Reactions, Pharmacokinetics, and Clinical Pharmacopsychology.基于药物不良反应、药代动力学和临床精神药理学的氯氮平合理应用。
Psychother Psychosom. 2020;89(4):200-214. doi: 10.1159/000507638. Epub 2020 Apr 14.
4
Evidence-based guidelines for the pharmacological treatment of schizophrenia: Updated recommendations from the British Association for Psychopharmacology.循证指南：英国精神药理学协会更新的精神分裂症药物治疗推荐。
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Editorial: Neurobiology, Clinical Course, and Therapeutic Approaches of Treatment-Resistant Schizophrenia: Toward an Integrated View.
Front Psychiatry. 2019 Nov 21;10:870. doi: 10.3389/fpsyt.2019.00870. eCollection 2019.
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The Gut Microbiome and Treatment-Resistance in Schizophrenia.肠道微生物组与精神分裂症的治疗抵抗。
Psychiatr Q. 2020 Mar;91(1):127-136. doi: 10.1007/s11126-019-09695-4.
7
Schizophrenia-An Overview.精神分裂症概述。
JAMA Psychiatry. 2020 Feb 1;77(2):201-210. doi: 10.1001/jamapsychiatry.2019.3360.
8
Real-World Outcomes in the Management of Refractory Psychosis.难治性精神病的现实世界结局。
J Clin Psychiatry. 2019 Sep 24;80(5):18m12716. doi: 10.4088/JCP.18m12716.
9
rTMS for clozapine refractory schizophrenia - A systematic review and pairwise meta-analysis.重复经颅磁刺激治疗氯氮平难治性精神分裂症——一项系统评价与成对荟萃分析
Schizophr Res. 2019 Sep;211:113-114. doi: 10.1016/j.schres.2019.07.004. Epub 2019 Jul 11.
10
Generation of refractory schizophrenia patient-derived induced pluripotent stem cell line UJSi001-A.难治性精神分裂症患者来源的诱导多能干细胞系UJSi001-A的生成。
Stem Cell Res. 2019 Jul;38:101460. doi: 10.1016/j.scr.2019.101460. Epub 2019 May 9.