Chen Yuanshu, Li Qin, Zhang Qianqian, Kou Juan, Zhang Yingying, Cui Han, Wernicke Jennifer, Montag Christian, Becker Benjamin, Kendrick Keith M, Yao Shuxia
The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Laboratory for NeuroInformation, Center for Information in Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Department of Molecular Psychology, Institute of Psychology and Education, Ulm University, Ulm, Germany.
Front Neurosci. 2020 Dec 4;14:589878. doi: 10.3389/fnins.2020.589878. eCollection 2020.
Manually-administered massage can potently increase endogenous oxytocin concentrations and neural activity in social cognition and reward regions and intranasal oxytocin can increase the pleasantness of social touch. In the present study, we investigated whether intranasal oxytocin modulates behavioral and neural responses to foot massage applied manually or by machine using a randomized placebo-controlled within-subject pharmaco-fMRI design. 46 male participants underwent blocks of massage of each type where they both received and imagined receiving the massage. Intranasal oxytocin significantly increased subjective pleasantness ratings of the manual but not the machine massage and neural responses in key regions involved in reward (orbitofrontal cortex, dorsal striatum and ventral tegmental area), social cognition (superior temporal sulcus and inferior parietal lobule), emotion and salience (amygdala and anterior cingulate and insula) and default mode networks (medial prefrontal cortex, parahippocampal gyrus, posterior cingulate, and precuneus) as well as a number of sensory and motor processing regions. Both neural and behavioral effects of oxytocin occurred independent of whether subjects thought the massage was applied by a male or female masseur. These findings support the importance of oxytocin for enhancing positive behavioral and neural responses to social touch in the form of manually administered massage and that a combination of intranasal oxytocin and massage may have therapeutic potential in autism.
The Effects of Oxytocin on Social Touch; registration ID: NCT03278860; URL: https://clinicaltrials.gov/ct2/show/NCT03278860.
手动按摩可显著提高内源性催产素浓度以及社交认知和奖赏区域的神经活动，而鼻内催产素可增强社交触摸的愉悦感。在本研究中，我们采用随机、安慰剂对照、受试者内药物功能磁共振成像设计，探究鼻内催产素是否会调节对手动或机器足部按摩的行为和神经反应。46名男性参与者接受了每种类型的按摩组，包括实际接受和想象接受按摩。鼻内催产素显著提高了手动按摩而非机器按摩的主观愉悦评分，以及奖赏（眶额皮质、背侧纹状体和腹侧被盖区）、社交认知（颞上沟和顶下小叶）、情绪和显著性（杏仁核、前扣带回和脑岛）、默认模式网络（内侧前额叶皮质、海马旁回、后扣带回和楔前叶）以及一些感觉和运动处理区域的关键区域的神经反应。催产素的神经和行为效应与受试者认为按摩是由男性还是女性按摩师进行无关。这些发现支持了催产素对于增强以手动按摩形式进行的社交触摸的积极行为和神经反应的重要性，并且鼻内催产素与按摩的组合可能对自闭症具有治疗潜力。
催产素对社交触摸的影响；注册号：NCT03278860；网址：https://clinicaltrials.gov/ct2/show/NCT03278860 。
