Departments of Biochemistry and Molecular Vascular Biology, Kanazawa University Graduate School of Medical Sciences, Kanazawa, 920-8640, Japan.
Department of Basic Research on Social Recognition and Memory, Research Centre for Child Mental Development, Kanazawa University, Kanazawa, 920-8640, Japan.
Commun Biol. 2020 Feb 13;3(1):70. doi: 10.1038/s42003-020-0799-2.
Oxytocin, a nonapeptide hormone, has a key role in female reproductive functions as well as in social memory in the brain. In our recent article, we reported that oxytocin is transported from the peripheral blood into the brain by the receptor for advanced glycation end-products (RAGE) in endothelial cells at the blood−brain barrier. Additionally, we found that oral oxytocin is absorbed by RAGE on intestinal epithelial cells at the blood−intestinal barrier. From a physiological perspective, we herein outline the continuing research regarding oxytocin and social behaviour.
催产素是一种九肽激素，它在女性生殖功能以及大脑中的社会记忆中起着关键作用。在我们最近的文章中，我们报道了催产素通过血脑屏障内皮细胞中的晚期糖基化终产物（RAGE）受体从外周血液中转运到大脑。此外，我们还发现口服催产素被血肠屏障的肠上皮细胞上的 RAGE 吸收。从生理学的角度来看，我们在此概述了关于催产素和社会行为的持续研究。
