Li Jingyi, Niu Chengcheng, Jiang Zichao, Zhang Zhen, Pan Yixiao, Xing Qiqi, Guo Qi, An Senbo, Hu Yihe, Wang Long
Department of Orthopedics, Xiangya Hospital, Central South University, Changsha, China.
Department of Orthopedics, Hunan Engineering Research Center of Biomedical Metal and Ceramic Implants, Xiangya Hospital, Central South University, Changsha, China.
Front Pharmacol. 2020 Dec 4;11:600156. doi: 10.3389/fphar.2020.600156. eCollection 2020.
Aseptic loosening induced by periprosthetic osteolysis (PPO) is the leading complication of total joint arthroplasty (TJA) and results in patients having to receive revision surgery. However, there is still no efficient drug to prevent or even slow the pathological process. Herein, we report novel dual-targeted, curcumin-loaded Poly lactic-co-glycolic acid nanoparticles (ZSCNPs) to inhibit polyethylene-induced osteolysis. These ZSCNPs have good biocompatibility and excellent bone binding affinity. Under external magnetic field guidance, the ZSCNPs can specifically target osteolytic sites with sustained curcumin release, efficiently suppress the effect of IκB kinase, subsequently inhibit activation of the nuclear factor-kappa B (NF-κB) signaling pathway, and ultimately prevent osteoclast formation and particle-induced osteolysis. Therefore, these novel dual-targeted, drug-loaded nanoparticles could be applied as a useful strategy for targeted treatment of PPO after TJA.
假体周围骨溶解（PPO）引发的无菌性松动是全关节置换术（TJA）的主要并发症，会导致患者不得不接受翻修手术。然而，目前仍没有有效的药物来预防甚至减缓这一病理过程。在此，我们报道了新型双靶向、负载姜黄素的聚乳酸-羟基乙酸共聚物纳米颗粒（ZSCNPs），以抑制聚乙烯诱导的骨溶解。这些ZSCNPs具有良好的生物相容性和出色的骨结合亲和力。在外加磁场引导下，ZSCNPs能够特异性靶向溶骨部位并持续释放姜黄素，有效抑制IκB激酶的作用，随后抑制核因子-κB（NF-κB）信号通路的激活，最终防止破骨细胞形成和颗粒诱导的骨溶解。因此，这些新型双靶向、载药纳米颗粒可作为TJA后PPO靶向治疗的有效策略。
