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尸检发现具有神经肌肉表现并伴有相关癌症的血管炎。

Vasculitis with a neuromuscular presentation and associated cancer revealed by autopsy.

作者信息

Nichols Larry, Karivelil Mathew Joseph

机构信息

Mercer University School of Medicine, Department of Pathology. Macon, GA, United States of America.

Mercer University School of Medicine. Macon, GA, United States of America.

出版信息

Autops Case Rep. 2020 May 12;10(2):e2020175. doi: 10.4322/acr.2020.175.

DOI:10.4322/acr.2020.175
PMID:33344289
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7703305/
Abstract

Peripheral neuropathy is common, but rarely due to vasculitis. This report is the case of a 74-year-old woman with systemic vasculitis who presented with progressive arm and leg weakness associated with numbness. Autopsy revealed a colon cancer, which may have triggered the vasculitis. This case illustrates the association between vasculitis and malignancy. The best treatment of vasculitis in patients with cancer-associated vasculitis is usually treatment of the cancer, which often yields remission of the vasculitis. This case also illustrates the difficulty of suspecting vasculitis since the symptoms and signs are nonspecific and protean. It is important not to miss a diagnosis of vasculitis. It is often life-threatening. It is treatable. The critical step in the diagnosis of vasculitis is to think of it.

摘要

周围神经病变很常见,但很少由血管炎引起。本报告介绍了一名74岁患有系统性血管炎的女性病例,该患者出现进行性手臂和腿部无力并伴有麻木感。尸检发现患有结肠癌,这可能引发了血管炎。该病例说明了血管炎与恶性肿瘤之间的关联。对于癌症相关性血管炎患者,血管炎的最佳治疗方法通常是治疗癌症,这往往会使血管炎得到缓解。该病例还说明了怀疑血管炎的困难之处,因为症状和体征不具特异性且多种多样。不漏诊血管炎很重要。它常常危及生命。它是可治疗的。血管炎诊断的关键步骤是想到它。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e543/7703305/787b8563e27f/autopsy-10-2-e2020175-gf03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e543/7703305/57e1f651f96e/autopsy-10-2-e2020175-gf01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e543/7703305/390a7ea68203/autopsy-10-2-e2020175-gf02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e543/7703305/787b8563e27f/autopsy-10-2-e2020175-gf03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e543/7703305/57e1f651f96e/autopsy-10-2-e2020175-gf01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e543/7703305/390a7ea68203/autopsy-10-2-e2020175-gf02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e543/7703305/787b8563e27f/autopsy-10-2-e2020175-gf03.jpg

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本文引用的文献

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The complexity of classifying ANCA-associated small-vessel vasculitis in actual clinical practice: data from a multicenter retrospective survey.在实际临床实践中对 ANCA 相关性小血管血管炎进行分类的复杂性:多中心回顾性调查数据。
Rheumatol Int. 2020 Feb;40(2):303-311. doi: 10.1007/s00296-019-04406-5. Epub 2019 Aug 5.
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Causes of chronic neuropathies: a single-center experience.慢性神经病变的病因:单中心经验。
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Peripheral Nerve Vasculitis: Classification and Disease Associations.
周围神经血管炎:分类和疾病关联。
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Vasculitis research: Current trends and future perspectives.血管炎研究:当前趋势与未来展望
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Approach to Peripheral Neuropathy for the Primary Care Clinician.基层医疗临床医师外周神经病变处理方法。
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2012 revised International Chapel Hill Consensus Conference Nomenclature of Vasculitides.2012年修订的国际 Chapel Hill 共识会议血管炎命名法
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Paraneoplastic vasculitis in patients with solid tumors: report of 15 cases.实体肿瘤患者的副肿瘤性血管炎:15例报告
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Vasculitides associated with malignancies: analysis of sixty patients.与恶性肿瘤相关的血管炎:60例患者的分析
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