Sevastopoulos C G, Glaser D A
Proc Natl Acad Sci U S A. 1977 Sep;74(9):3947-50. doi: 10.1073/pnas.74.9.3947.
Several newly isolated temperature-sensitive dnaE mutants of Escherichia coli exhibit powerful mutagenic action at permissive temperatures. Mutation rates for the two most active mutants were assayed at four different temperatures and compared to wild-type behavior. Temperature-resistant revertants of the original temperature-sensitive dnaE mutants exhibited lower, nearly normal, mutation rates, but no antimutator strains were found.
几种新分离出的大肠杆菌温度敏感型 dnaE 突变体在允许温度下表现出强大的诱变作用。在四个不同温度下测定了两个活性最强的突变体的突变率，并与野生型行为进行了比较。原始温度敏感型 dnaE 突变体的温度抗性回复体表现出较低的、近乎正常的突变率，但未发现抗诱变菌株。
