Department of Biochemistry & Molecular Medicine, Faculty of Medicine, Universiti Teknologi MARA, Cawangan Selangor, Kampus Sungai Buloh, 47000 Sungai Buloh, Selangor, Malaysia.
Institute of Medical & Molecular Biotechnology, Faculty of Medicine, Universiti Teknologi MARA, Cawangan Selangor, Kampus Sungai Buloh, 47000 Sungai Buloh, Selangor, Malaysia.
Biomed Res Int. 2020 Dec 3;2020:5197626. doi: 10.1155/2020/5197626. eCollection 2020.
Equilibrative nucleoside transporter 2 (ENT2) is a bidirectional transporter embedded in the biological membrane and is ubiquitously found in most tissue and cell types. ENT2 mediates the uptake of purine and pyrimidine nucleosides and nucleobase besides transporting a variety of nucleoside-derived drugs, mostly in anticancer therapy. Since high expression of ENT2 has been correlated with advanced stages of different types of cancers, consequently, this has gained significant interest in the role of ENT2 as a potential therapeutic target. Furthermore, ENT2 plays critical roles in signaling pathway and cell cycle progression. Therefore, elucidating the physiological roles of ENT2 and its properties may contribute to a better understanding of ENT2 roles beyond their transportation mechanism. This review is aimed at highlighting the main roles of ENT2 and at providing a brief update on the recent research.
平衡核苷转运蛋白 2（ENT2）是一种双向转运蛋白，嵌入生物膜中，广泛存在于大多数组织和细胞类型中。ENT2 除了转运多种核苷衍生药物外，还介导嘌呤和嘧啶核苷以及核苷碱基的摄取，这些药物主要用于癌症治疗。由于 ENT2 的高表达与不同类型癌症的晚期阶段相关，因此，ENT2 作为潜在治疗靶点的作用引起了人们的极大关注。此外，ENT2 在信号通路和细胞周期进展中发挥关键作用。因此，阐明 ENT2 的生理作用及其特性可能有助于更好地理解 ENT2 的作用，而不仅仅局限于其运输机制。本文旨在强调 ENT2 的主要作用，并提供有关最新研究的简要更新。
