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基于碳纳米管作为磁靶向因子和药物载体的新型Span-PEG多功能超声造影剂

Novel Span-PEG Multifunctional Ultrasound Contrast Agent Based on CNTs as a Magnetic Targeting Factor and a Drug Carrier.

作者信息

Zhang Jie, Liu Zhongtao, Zhou Shujing, Teng Yang, Zhang Xiangyu, Li Jinjing

机构信息

Pharmacy College, Jiamusi university, Jiamusi 154007, China.

出版信息

ACS Omega. 2020 Dec 1;5(49):31525-31534. doi: 10.1021/acsomega.0c03325. eCollection 2020 Dec 15.

DOI:10.1021/acsomega.0c03325
PMID:33344804
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7745219/
Abstract

Based on the targeting of ferroferric oxide (FeO) and the drug-loading property of carbon nanotubes (CNTs), a novel Span-PEG-composited FeO-CNTs-DOX multifunctional ultrasound contrast agent was designed and applied to tumor lesions. In situ liquid phase synthesis was employed to prepare the FeO-CNTs magnetic targeting complex, and the physical method was used to obtain the FeO-CNTs-DOX complex by loading doxorubicin (DOX) onto FeO-CNTs. The targeted drug-loading complex FeO-CNTs-DOX was combined with the membrane material of Span-PEG by the acoustic vibration cavitation method. The maximum tolerance for Span-PEG-composited FeO-CNTs-DOX microbubbles was 450 times higher, which has good safety. The loading rate of DOX in the obtained composite microbubbles was 17.02%. The proliferation inhibition rate of Span-PEG-composited FeO-CNTs-DOX microbubbles on liver cancer SMMC-7721 cells reached 48.3%. Span-PEG-composited FeO-CNTs-DOX microbubbles could significantly enhance ultrasonic imaging and enrich at a specific location under an external magnetic field, and the extended imaging time could ensure the effective observation and diagnosis of lesions.

摘要

基于三氧化二铁（FeO）的靶向性和碳纳米管（CNTs）的载药特性，设计了一种新型的Span-PEG复合FeO-CNTs-DOX多功能超声造影剂并将其应用于肿瘤病灶。采用原位液相合成法制备FeO-CNTs磁性靶向复合物，通过将阿霉素（DOX）负载到FeO-CNTs上，利用物理方法获得FeO-CNTs-DOX复合物。采用声振空化法将靶向载药复合物FeO-CNTs-DOX与Span-PEG膜材料复合。Span-PEG复合FeO-CNTs-DOX微泡的最大耐受量高450倍，具有良好的安全性。所得复合微泡中DOX的载药率为17.02%。Span-PEG复合FeO-CNTs-DOX微泡对肝癌SMMC-7721细胞的增殖抑制率达48.3%。Span-PEG复合FeO-CNTs-DOX微泡可显著增强超声成像，并在外加磁场作用下在特定位置富集，延长的成像时间可确保对病灶进行有效观察和诊断。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d45f/7745219/11ccc67f16da/ao0c03325_0015.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d45f/7745219/c8f3fbcdad44/ao0c03325_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d45f/7745219/5f15e622d492/ao0c03325_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d45f/7745219/14ff01d81763/ao0c03325_0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d45f/7745219/e0800dda5096/ao0c03325_0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d45f/7745219/971a4e1e8024/ao0c03325_0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d45f/7745219/4f05bf3aea29/ao0c03325_0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d45f/7745219/ef678e18fe72/ao0c03325_0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d45f/7745219/d2fb4aca3c28/ao0c03325_0009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d45f/7745219/c03faa341904/ao0c03325_0010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d45f/7745219/5908701f39f5/ao0c03325_0011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d45f/7745219/1f647b3ff795/ao0c03325_0012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d45f/7745219/d398433eec15/ao0c03325_0013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d45f/7745219/5f88ed42380e/ao0c03325_0014.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d45f/7745219/11ccc67f16da/ao0c03325_0015.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d45f/7745219/c8f3fbcdad44/ao0c03325_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d45f/7745219/5f15e622d492/ao0c03325_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d45f/7745219/14ff01d81763/ao0c03325_0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d45f/7745219/e0800dda5096/ao0c03325_0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d45f/7745219/971a4e1e8024/ao0c03325_0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d45f/7745219/4f05bf3aea29/ao0c03325_0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d45f/7745219/ef678e18fe72/ao0c03325_0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d45f/7745219/d2fb4aca3c28/ao0c03325_0009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d45f/7745219/c03faa341904/ao0c03325_0010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d45f/7745219/5908701f39f5/ao0c03325_0011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d45f/7745219/1f647b3ff795/ao0c03325_0012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d45f/7745219/d398433eec15/ao0c03325_0013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d45f/7745219/5f88ed42380e/ao0c03325_0014.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d45f/7745219/11ccc67f16da/ao0c03325_0015.jpg

相似文献

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[2]
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[2]
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[3]
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[4]
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[5]
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[6]
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本文引用的文献

[1]
Enhanced ultrasound imaging and anti-tumor properties of Span-polyethylene glycol with folic acid-carbon nanotube-paclitaxel multifunctional microbubbles.

RSC Adv. 2019-10-31

[2]
New Span-PEG-composited FeO-CNT as a multifunctional ultrasound contrast agent for inflammation and thrombotic niduses.

RSC Adv. 2020-10-20

[3]
New FH peptide-modified ultrasonic nanobubbles for delivery of doxorubicin to cancer-associated fibroblasts.

Nanomedicine (Lond). 2019-11-21

[4]
Ultrasound-controlled DOX-SiO nanocomposites enhance the antitumour efficacy and attenuate the toxicity of doxorubicin.

Nanoscale. 2019-3-7

[5]
Paclitaxel Encapsulation into Dual-Functionalized Multi-Walled Carbon Nanotubes.

AAPS PharmSciTech. 2019-1-7

[6]
Aptamer-conjugated multi-walled carbon nanotubes as a new targeted ultrasound contrast agent for the diagnosis of prostate cancer.

J Nanopart Res. 2018

[7]
Stacking of doxorubicin on folic acid-targeted multiwalled carbon nanotubes for in vivo chemotherapy of tumors.

Drug Deliv. 2018-11

[8]
PEGylated multi-walled carbon nanotubes as versatile vector for tumor-specific intracellular triggered release with enhanced anti-cancer efficiency: Optimization of length and PEGylation degree.

Colloids Surf B Biointerfaces. 2018-2-20

[9]
Targeted delivery and controlled release of Paclitaxel for the treatment of lung cancer using single-walled carbon nanotubes.

Mater Sci Eng C Mater Biol Appl. 2016-11-1

[10]
Effects of transferrin conjugated multi-walled carbon nanotubes in lung cancer delivery.

Mater Sci Eng C Mater Biol Appl. 2016-10-1

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