Dipartimento di Ambiente e Salute, Istituto Superiore di Sanità, Rome, Italy.
Servizio di Statistica, Istituto Superiore di Sanità, Rome, Italy.
Ann Ist Super Sanita. 2020 Oct-Dec;56(4):478-486. doi: 10.4415/ANN_20_04_10.
Malignant mesothelioma (MM) is a rare neoplasm caused by asbestos. Mortality from MM in ≤50 years old people, considering the long latency, is likely related to asbestos exposure in childhood. Mortality from MM (C45, ICD10 code) is described among ≤50 years (ys) old people in Italy, in 2003-2016. National and regional Standardized Rates (SRs) were computed by age-class. The North-South trend of regional SRs, increasing in >50ys age-class, showed a flat cline in ≤50ys old people. Municipal Standardized Mortality Ratios (SMRs) were computed, with respect to regional figures, for ≤50 ys old population. In Italy, 487 people ≤50 ys old died from MM, in 2003-2016 (2.5% of all MM deaths), corresponding to 35/year. The highest SMRs were observed in Northern Regions, the most industrialized areas. Exceeding SMRs were found in 10 municipalities where former asbestos-cement plants, shipyards, and a quarry contaminated by fluoro-edenite fibres were present. Early mortality from MM, proxy of childhood environmental asbestos exposure, deserves particular concern.
恶性间皮瘤（MM）是一种罕见的由石棉引起的肿瘤。考虑到潜伏期较长，≤50 岁人群中 MM 的死亡率可能与儿童时期的石棉暴露有关。2003-2016 年，意大利报道了≤50 岁（ys）人群中 MM（C45，ICD10 代码）的死亡率。按年龄组计算了全国和地区标准化死亡率（SR）。地区 SR 的南北趋势，在>50 岁年龄组中增加，在≤50 岁的人群中呈现出平坦的梯度。根据地区数据，计算了≤50 岁人群的城市标准化死亡率比（SMR）。在意大利，2003-2016 年间，有 487 名≤50 岁的人死于 MM（占所有 MM 死亡人数的 2.5%），每年约 35 例。在工业化程度最高的北部地区，SMR 最高。在 10 个存在以前的石棉水泥厂、造船厂和被氟闪石纤维污染的采石场的城市中，发现了超过 SMR 的情况。MM 的早期死亡率是儿童时期环境石棉暴露的代表，值得特别关注。
