Correction of Skin Depressions of the Hands and Décolletage With VYC-17.5L: A Prospective, Single-center Study.

BACKGROUND

Few studies have assessed the use of hyaluronic acid (HA) fillers for rejuvenating the hands and décolletage. VYC-17.5L is an HA filler with physical properties that may be well suited to these areas.

METHODS

This was a prospective study of females undergoing VYC-17.5L treatment in the dorsum of both hands and the décolletage. All had ageing of the hands rated 3–4 on the Allergan Hand Volume Deficit Scale (AHVDS), and of the décolletage rated 3–5 using the Fabi–Bolton Chest Wrinkle Scale (FBCWS). Patients were initially treated with VYC-17.5L up to a maximum of 1.5 mL per hand and 3.0 mL in the décolletage; VYC-17.5L touch up was allowed at 1 month. Subjects were followed up for 12 months. The primary endpoint was the number of responders in each hand and the décolletage at 6 months, defined as a ≥ 1-point improvement on AHVDS or FBCWS.

RESULTS

Thirty-three patients were enrolled (mean age, 56.6 ± 9.9 years). Six-month response rates were 100% in each hand (AHVDS) and 96.9% in the décolletage (FBCWS). Mean improvements were statistically significant at all three sites (P<0.001). At 6 months, patient satisfaction using the Global Aesthetic Improvement Scale was high: 81.3% rated their right and left hands as ‘improved’ or ‘much improved’; 65.6% rated their décolletage this way. Results were durable out to 12 months for all endpoints. There were no unexpected safety findings.

CONCLUSIONS

VYC-17.5L was effective and safe for correction of skin depressions of the hands and décolletage. J Drugs Dermatol. 2020;19(12): doi:10.36849/JDD.2020.5524.