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透明质酸注射后单侧视力丧失:一例报告

Unilateral Vision Loss After Hyaluronic Acid Injection: A Case Report.

作者信息

Hung Jia-Horung, Wang Chung-Ting, Lee Chaw-Ning, Shieh Shyh-Jou

机构信息

School of Medicine.

Department of Dermatology.

出版信息

Ann Plast Surg. 2021 Feb 1;86(2S Suppl 1):S127-S131. doi: 10.1097/SAP.0000000000002624.

DOI:10.1097/SAP.0000000000002624
PMID:33346533
Abstract

Vascular occlusion causing vision loss is a rare yet one of the most devastating complications of facial esthetic fillers. In this article, we present a case of unilateral blindness and superficial skin necrosis in a 31-year-old woman after the injection of hyaluronic acid for esthetic purposes. The delicate ocular fundal findings of ophthalmic artery occlusion were demonstrated by ophthalmoscopy, optical coherence tomography, and fluorescein angiography. Magnetic resonance imaging also showed subsequent ischemic changes in the optic nerve and posterior scleral wall after ophthalmic artery occlusion. Despite management including intraocular pressure-lowering agents, globe massage, and anticoagulation with acetylsalicylic acid and hyperbaric oxygen therapy, her final vision was not restored. Given the lack of effective treatments, this report depicts the comprehensive ocular fundal findings of an ophthalmic artery occlusion after esthetic hyaluronic acid filler injection, and highlights the importance of a preventive approach to avoid such catastrophic complications.

摘要

血管阻塞导致视力丧失是面部美容填充剂罕见但最具破坏性的并发症之一。在本文中,我们报告了一例31岁女性在注射透明质酸进行美容后出现单侧失明和浅表皮肤坏死的病例。通过眼底镜检查、光学相干断层扫描和荧光素血管造影显示了眼动脉阻塞的精细眼底表现。磁共振成像还显示了眼动脉阻塞后视神经和巩膜后壁随后的缺血性改变。尽管采取了包括降低眼压药物、眼球按摩以及使用乙酰水杨酸抗凝和高压氧治疗等措施,但其最终视力仍未恢复。鉴于缺乏有效的治疗方法,本报告描述了美容透明质酸填充剂注射后眼动脉阻塞的全面眼底表现,并强调了采取预防措施以避免此类灾难性并发症的重要性。

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1
Unilateral Vision Loss After Hyaluronic Acid Injection: A Case Report.透明质酸注射后单侧视力丧失:一例报告
Ann Plast Surg. 2021 Feb 1;86(2S Suppl 1):S127-S131. doi: 10.1097/SAP.0000000000002624.
2
Severe vision loss caused by cosmetic filler augmentation: Case series with review of cause and therapy.美容填充剂注射导致的严重视力丧失:病例系列及病因与治疗综述
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Iatrogenic retinal artery occlusion caused by cosmetic facial filler injections.由美容面部填充物注射引起的医源性视网膜动脉阻塞。
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Cerebral Angiographic Findings of Cosmetic Facial Filler-related Ophthalmic and Retinal Artery Occlusion.美容面部填充剂相关的眼动脉和视网膜动脉阻塞的脑血管造影表现
J Korean Med Sci. 2015 Dec;30(12):1847-55. doi: 10.3346/jkms.2015.30.12.1847. Epub 2015 Nov 30.
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Clinical Observations and the Anatomical Basis of Blindness After Facial Hyaluronic Acid Injection.面部透明质酸注射后失明的临床观察及解剖学基础
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Ophthalmoplegia with skin necrosis after a hyaluronic acid filler injection.透明质酸填充剂注射后出现眼肌瘫痪伴皮肤坏死。
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Intra-Arterial Thrombolytic Therapy Is Not a Therapeutic Option for Filler-Related Central Retinal Artery Occlusion.动脉内溶栓治疗并非填充剂相关的视网膜中央动脉阻塞的治疗选择。
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引用本文的文献

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"Filler-Associated Acute Stroke Syndrome": Classification, Predictive Modelling of Hyaluronidase Efficacy, and Updated Case Review on Neurological and Visual Complications.“填充剂相关急性卒中综合征”:分类、透明质酸酶疗效的预测模型,以及神经和视觉并发症的最新病例复习。
Aesthetic Plast Surg. 2024 Sep;48(17):3222-3253. doi: 10.1007/s00266-024-04202-y. Epub 2024 Jul 7.
2
Complete Vision Recovery After Filler-Induced Blindness Using Hyperbaric Oxygen Therapy: Case Report and Literature Review.高压氧治疗填充剂致盲后视力完全恢复:病例报告与文献综述
Aesthet Surg J Open Forum. 2024 May 15;6:ojae036. doi: 10.1093/asjof/ojae036. eCollection 2024.
3
Clinical Manifestations and Prognosis of Embolism Caused by Filler Injection in Different Facial Regions.
不同面部区域填充剂注射所致栓塞的临床表现及预后
Plast Reconstr Surg Glob Open. 2023 Aug 29;11(8):e5225. doi: 10.1097/GOX.0000000000005225. eCollection 2023 Aug.
4
Retrospective Study of Vascular Complications Caused by Hyaluronic Acid Injection.透明质酸注射引起的血管并发症的回顾性研究。
Aesthetic Plast Surg. 2023 Dec;47(6):2745-2753. doi: 10.1007/s00266-023-03522-9. Epub 2023 Aug 14.
5
Vision Loss and Blindness Following Fillers.填充剂注射后的视力丧失与失明
J Dermatol Skin Sci. 2021;3(2):1-4. Epub 2021 May 26.