The First School of Clinical Medicine, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong 510405, China.
Department of Oncology, Shenzhen Hospital (Futian) of Guangzhou University of Chinese Medicine, Shenzhen, Guangdong 518000, China.
Biosci Rep. 2021 Jan 29;41(1). doi: 10.1042/BSR20203594.
Hepatocellular carcinoma (HCC) is a malignant tumor with rapid progression, high recurrence rate and poor prognosis. The objective of our investigation was to explore the prognostic value of CDK5R1 in HCC.
The raw data of HCC raw data were downloaded from The Cancer Genome Atlas (TCGA) database. The Wilcoxon signed-rank test, Kruskal-Wallis test and logistic regression were applied to investigate the relevance between the CDK5R1 expression and clinicopathologic characteristics in HCC. Kaplan-Meier and Cox regression analysis were employed to examine the association between clinicopathologic features and survival. Gene set enrichment analysis (GSEA) was applied to annotate the biological function of CDK5R1.
CDK5R1 was highly expressed in HCC tissues. The high expression of CDK5R1 in HCC tissues was significantly associated with tumor status (P=0.00), new tumor event (P=0.00), clinical stage (P=0.00) and topography (P=0.00). Elevated CDK5R1 had significant correlation with worse overall survival (OS; P=7.414e-04), disease-specific survival (DSS; P=5.642e-04), disease-free interval (DFI; P=1.785e-05) and progression-free interval (PFI; P=2.512e-06). Besides, univariate and multivariate Cox regression analysis uncovered that increased CDK5R1 can independently predict adverse OS (P=0.037, hazard ratio [HR]= 1.7 (95% CI [1.0-2.7])), DFI (P=0.007, hazard ratio [HR]= 3.0 (95% CI [1.4-6.7])), PFI (P=0.007, hazard ratio [HR]= 2.8 (95% CI [1.3-5.9])). GSEA disclosed that notch signaling pathway and non-small cell lung cancer were prominently enriched in CDK5R1 high expression phenotype.
Increased CDK5R1 may act as a promising independent prognostic factor of poor survival in HCC.
肝细胞癌（HCC）是一种恶性肿瘤，具有进展迅速、复发率高、预后差的特点。本研究旨在探讨 CDK5R1 在 HCC 中的预后价值。
从癌症基因组图谱（TCGA）数据库中下载 HCC 原始数据。采用 Wilcoxon 符号秩检验、Kruskal-Wallis 检验和逻辑回归分析 CDK5R1 表达与 HCC 临床病理特征的相关性。Kaplan-Meier 和 Cox 回归分析用于检验临床病理特征与生存的关系。基因集富集分析（GSEA）用于注释 CDK5R1 的生物学功能。
CDK5R1 在 HCC 组织中高表达。HCC 组织中 CDK5R1 的高表达与肿瘤状态（P=0.00）、新发肿瘤事件（P=0.00）、临床分期（P=0.00）和肿瘤部位（P=0.00）显著相关。CDK5R1 升高与总生存期（OS；P=7.414e-04）、疾病特异性生存期（DSS；P=5.642e-04）、无病间隔（DFI；P=1.785e-05）和无进展间隔（PFI；P=2.512e-06）显著相关。此外，单因素和多因素 Cox 回归分析表明，CDK5R1 升高可独立预测不良 OS（P=0.037，风险比 [HR]=1.7（95% CI [1.0-2.7]））、DFI（P=0.007，风险比 [HR]=3.0（95% CI [1.4-6.7]））、PFI（P=0.007，风险比 [HR]=2.8（95% CI [1.3-5.9]））。GSEA 表明，Notch 信号通路和非小细胞肺癌在 CDK5R1 高表达表型中显著富集。
CDK5R1 升高可能是 HCC 患者不良生存的一个有前途的独立预后因素。
