In Silico Identification of Contradictory Role of ADAMTS5 in Hepatocellular Carcinoma.

BACKGROUND

has different roles in multiple types of cancers and participates in various molecular mechanisms. However, the prognostic value of in patients with hepatocellular carcinoma (HCC) still remains unclear. We carried the study to evaluate the prognostic value and identified underlying molecular mechanisms in HCC.

METHODS

Firstly, the association of expression and clinicopathological parameters was evaluated by in GSE14520. Next, expression in HCC was performed using GSE14520, GSE36376, GSE76427 and The Cancer Genome Atlas (TCGA) profile. Furthermore, Kaplan-Meier analysis, Univariate and Multivariate Cox regression analysis, subgroup analysis was performed to evaluate the prognostic value in HCC. Finally, GO enrichment analysis, gene set enrichment analysis (GSEA) and weighted gene co-expression network analysis (WGCNA) were performed to revealed underlying molecular mechanisms.

RESULT

The expression of was positively correlated with the development of HCC. Next, high expression was significantly associated with poorer survival (all < 0.05) and the impact of on all overall survival (OS), disease-free survival (DFS), relapse-free survival (RFS), disease specific survival (DSS) and progression free interval (PFI) was specific for HCC among other 29 cancer types. Subgroup analysis showed that overexpression was significantly associated with poorer OS in patients with HCC. Finally, might participate in the status conversion from metabolic-dominant to extracellular matrix-dominant, and the activation of ECM-related biological process might contribute to high higher mortality risk for patients with HCC.

CONCLUSION

may play an important role in the progression of HCC, and may be considered as a novel and effective biomarker for predicting prognosis for patients with HCC.