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EMBO J. 2021 Jan 15;40(2):e107097. doi: 10.15252/embj.2020107097. Epub 2020 Dec 21.
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本文引用的文献

1
A stress-induced tyrosine-tRNA depletion response mediates codon-based translational repression and growth suppression.应激诱导的酪氨酸-tRNA 耗竭反应介导基于密码子的翻译抑制和生长抑制。
EMBO J. 2021 Jan 15;40(2):e106696. doi: 10.15252/embj.2020106696. Epub 2020 Dec 21.
2
tRNA-Derived Small RNAs: Biogenesis, Modification, Function and Potential Impact on Human Disease Development.转运RNA衍生的小RNA：生物合成、修饰、功能及其对人类疾病发展的潜在影响
Genes (Basel). 2018 Dec 5;9(12):607. doi: 10.3390/genes9120607.
3
Cells alter their tRNA abundance to selectively regulate protein synthesis during stress conditions.细胞改变其 tRNA 丰度以选择性地调节应激条件下的蛋白质合成。
Sci Signal. 2018 Sep 4;11(546):eaat6409. doi: 10.1126/scisignal.aat6409.
4
Pseudouridylation of tRNA-Derived Fragments Steers Translational Control in Stem Cells.tRNA 衍生片段的假尿嘧啶化调控干细胞中的翻译调控。
Cell. 2018 May 17;173(5):1204-1216.e26. doi: 10.1016/j.cell.2018.03.008. Epub 2018 Apr 5.
5
Transcriptome-wide Analysis of Roles for tRNA Modifications in Translational Regulation.全转录组范围分析tRNA修饰在翻译调控中的作用
Mol Cell. 2017 Dec 7;68(5):978-992.e4. doi: 10.1016/j.molcel.2017.11.002. Epub 2017 Nov 30.
6
Stem cell function and stress response are controlled by protein synthesis.干细胞功能和应激反应受蛋白质合成的调控。
Nature. 2016 Jun 16;534(7607):335-40. doi: 10.1038/nature18282.
7
Modulated Expression of Specific tRNAs Drives Gene Expression and Cancer Progression.特定转运RNA的调控表达驱动基因表达和癌症进展。
Cell. 2016 Jun 2;165(6):1416-1427. doi: 10.1016/j.cell.2016.05.046.
8
Endogenous tRNA-Derived Fragments Suppress Breast Cancer Progression via YBX1 Displacement.内源性tRNA衍生片段通过取代YBX1抑制乳腺癌进展。
Cell. 2015 May 7;161(4):790-802. doi: 10.1016/j.cell.2015.02.053.
9
A dual program for translation regulation in cellular proliferation and differentiation.细胞增殖和分化中翻译调控的双重程序。
Cell. 2014 Sep 11;158(6):1281-1292. doi: 10.1016/j.cell.2014.08.011.
10
Reprogramming of tRNA modifications controls the oxidative stress response by codon-biased translation of proteins.tRNA 修饰的重编程通过密码子偏倚性翻译控制氧化应激反应。
Nat Commun. 2012 Jul 3;3:937. doi: 10.1038/ncomms1938.

应激与切割：应激诱导的 tRNA 片段化通过密码子适应性来抑制细胞生长。

Stressin' and slicin': stress-induced tRNA fragmentation codon-adapts translation to repress cell growth.

机构信息

Division of Molecular Hematology, Department of Laboratory Medicine, Lund Stem Cell Center, Faculty of Medicine, Lund University, Lund, Sweden.

出版信息

EMBO J. 2021 Jan 15;40(2):e107097. doi: 10.15252/embj.2020107097. Epub 2020 Dec 21.

DOI:10.15252/embj.2020107097
PMID:33346912
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7809787/
Abstract

Transfer RNAs (tRNAs) are central adaptors that decode genetic information during translation and have been long considered static cellular components. However, whether dynamic changes in tRNAs and tRNA-derived fragments actively contribute to gene regulation remains debated. In this issue, Huh et al (2020) highlight tyrosine tRNA fragmentation at the nexus of an evolutionarily conserved adaptive codon-based stress response that fine-tunes translation to restrain growth in human cells.

摘要

转移 RNA（tRNA）是在翻译过程中解码遗传信息的核心适配器，长期以来一直被视为静态细胞成分。然而，tRNA 及其衍生片段的动态变化是否积极参与基因调控仍存在争议。在本期杂志中，Huh 等人（2020 年）强调了酪氨酸 tRNA 片段化在进化上保守的基于适应密码子的应激反应的交汇点，这种反应可以精细调节翻译，从而抑制人类细胞的生长。