From the Department of Pathology, Emory University, Atlanta, GA.
Department of Pathology, Western Michigan University Homer Stryker MD School of Medicine, Kalamazoo, MI.
Am J Forensic Med Pathol. 2021 Sep 1;42(3):297-300. doi: 10.1097/PAF.0000000000000646.
Thromboangiitis obliterans (TAO, Buerger disease) is a segmental, non-atherosclerotic vasculitis that causes occlusion of the small and medium sized vessels of the distal extremities. In rare cases, it can affect vessels in the gastrointestinal, cerebrovascular, coronary, and renal systems. The etiology of thromboangiitis obliterans is unknown, but there is a strong association with smoking in the development and the progression of the disease. We present the case of a 42-year-old homeless female smoker, who was found dead outdoors. Although originally suspected to be a possible trauma-related death, autopsy revealed a thrombus in her left carotid artery, which caused an acute cerebral infarction. It was concluded that thromboangiitis obliterans, likely precipitated by smoking, was the cause of the thrombosis and subsequent death.
血栓闭塞性脉管炎(TAO,伯格氏病)是一种节段性、非动脉粥样硬化性血管炎,可导致远端中小血管闭塞。在极少数情况下,它可影响胃肠道、脑血管、冠状动脉和肾脏系统的血管。血栓闭塞性脉管炎的病因尚不清楚,但吸烟与疾病的发生和进展有很强的关联。我们报告了一例 42 岁的流浪女性吸烟者,她被发现死在户外。虽然最初怀疑可能是与创伤相关的死亡,但尸检显示她的左颈动脉有血栓,导致急性脑梗死。结论为血栓闭塞性脉管炎,可能由吸烟引发,是血栓形成和随后死亡的原因。