Rana Ramesh, Bhattacharya Satyadeep, Bhattacharya Baishali, Ghimire Ram K, Joshi Neeraj
Department of Gastroenterology and Hepatology.
Department of Colorectal Surgery.
Ann Med Surg (Lond). 2024 Apr 29;86(6):3770-3775. doi: 10.1097/MS9.0000000000002111. eCollection 2024 Jun.
Buerger's disease is an uncommon segmental nonatherosclerotic vasculitis essentially affecting small to medium-sized arteries and veins of upper and lower extremities and can lead to limb amputation. Visceral vessel involvement is quite rare accounting for 2% of cases presenting with acute abdomen due to mesenteric ischemia. Moreover, isolated visceral involvement is even rare.
A 42-year-old gentleman, a chronic smoker, presented with abdominal pain associated with nausea and vomiting and loose stool of 2 months duration. Magnetic resonance enterography revealed segmental circumferential wall thickening with stricture in the mid part of the jejunum with lymphadenopathy features of possible inflammatory bowel disease (Crohn's disease). Furthermore, intraoperative surgical findings were also suggestive of Crohn's disease. However, histologic findings were consistent with thromboangiitis obliterans.
Thromboangiitis obliterans can present with inflammatory vascular lesions without necrosis in the early stage to varying degrees of recanalisation, gangrene, and amputation in the late stage. It rarely involves the brain, heart, and abdominal viscera. The visceral involvement may be in the form of intestinal obstruction or mesenteric ischemia or can mimic Crohn's in a background of smoking.
This case report will help to learn more about the rarer intestinal presentation of intestinal Buerger's disease. It can present with features of bowel ischemia, obstruction or Crohn's. So, histology would play a pivotal role in differentiating the diagnostic dilemma.
血栓闭塞性脉管炎是一种罕见的节段性非动脉粥样硬化性血管炎,主要累及上下肢的中小动脉和静脉,可导致肢体截肢。内脏血管受累相当罕见,占因肠系膜缺血导致急腹症病例的2%。此外,孤立的内脏受累更为罕见。
一名42岁男性,长期吸烟者,出现腹痛伴恶心、呕吐及持续2个月的腹泻。磁共振小肠造影显示空肠中部节段性环形肠壁增厚伴狭窄,有可能为炎症性肠病(克罗恩病)的淋巴结肿大特征。此外,术中手术所见也提示克罗恩病。然而,组织学检查结果与血栓闭塞性脉管炎相符。
血栓闭塞性脉管炎在早期可表现为炎症性血管病变而无坏死,后期可出现不同程度的再通、坏疽和截肢。它很少累及脑、心脏和腹部脏器。内脏受累可能表现为肠梗阻或肠系膜缺血,或在吸烟背景下可类似克罗恩病。
本病例报告将有助于更多地了解血栓闭塞性脉管炎较罕见的肠道表现。它可表现为肠缺血、梗阻或克罗恩病的特征。因此,组织学检查在区分诊断难题中起关键作用。