Department of Oncology, Affiliated People's Hospital of Jiangsu University, Zhenjiang, Jiangsu, China.
Department of Clinical Laboratory, Fujian Medical University Union Hospital, Fuzhou, Fujian, China.
DNA Cell Biol. 2021 Feb;40(2):384-392. doi: 10.1089/dna.2020.6089. Epub 2020 Dec 21.
Colorectal cancer (CRC) is a common cancer threatening human health. Intercellular adhesion molecule-1 (ICAM-1, CD54) displays a key role in carcinogenesis and previous studies have suggested that single-nucleotide polymorphisms (SNPs) are predicted to increase the risk of CRC. However, the relationship of SNPs with CRC susceptibility was controversial. We conducted a case-control study to clarify the association of SNPs (rs5498 and rs3093030) with the CRC risk. A total of 1003 CRC patients and 1303 controls were recruited to determine SNPs (rs5498 and rs3093030) by SNPscan method. In the case-control study, we found that rs5498 polymorphism did not influence CRC risk (AG vs. AA: adjusted = 0.179; GG vs. AA: adjusted = 0.281, AG+GG vs. AA: adjusted = 0.398; GG vs. AA+AG: adjusted = 0.153), and rs3093030 polymorphism did not influence CRC risk (CT vs. CC: adjusted = 0.841; TT vs. CC: adjusted = 0.175, CT+TT vs. CC: adjusted = 0.574 and TT vs. CC+TT: adjusted = 0.180). In a subgroup of age >61, rs5498 decreased the risk of CRC ( = 0.047). Multivariate analysis revealed that smoking ( = 0.002; odds ratio [OR]: 1.76, 95% confidence interval [CI]: 1.18-2.63), alcohol intake ( < 0.001; OR: 1.99, 95% CI: 1.31-3.05), and body mass index <24 ( < 0.001; OR: 1.55, 95% CI: 1.06-2.26) increased the risk of CRC. Our findings showed that rs3093030 was not correlated with the susceptibility of CRC, and rs5498 increased the risk of CRC in the subgroup of age ≥61. In the future, larger and ethnically homogeneous populations are needed to confirm our results.
结直肠癌（CRC）是一种威胁人类健康的常见癌症。细胞间黏附分子-1（ICAM-1，CD54）在致癌作用中起关键作用，先前的研究表明，单核苷酸多态性（SNPs）可预测 CRC 风险增加。然而，SNP 与 CRC 易感性的关系存在争议。我们进行了一项病例对照研究，以阐明 SNPs（rs5498 和 rs3093030）与 CRC 风险的关系。共招募了 1003 例 CRC 患者和 1303 例对照，采用 SNPscan 法检测 SNPs（rs5498 和 rs3093030）。在病例对照研究中，我们发现 rs5498 多态性不影响 CRC 风险（AG 与 AA：调整后=0.179；GG 与 AA：调整后=0.281，AG+GG 与 AA：调整后=0.398；GG 与 AA+AG：调整后=0.153），rs3093030 多态性不影响 CRC 风险（CT 与 CC：调整后=0.841；TT 与 CC：调整后=0.175，CT+TT 与 CC：调整后=0.574，TT 与 CC+TT：调整后=0.180）。在年龄>61 岁的亚组中，rs5498 降低了 CRC 的风险（=0.047）。多变量分析显示，吸烟（=0.002；比值比[OR]：1.76，95%置信区间[CI]：1.18-2.63）、饮酒（<0.001；OR：1.99，95% CI：1.31-3.05）和 BMI<24（<0.001；OR：1.55，95% CI：1.06-2.26）增加了 CRC 的风险。我们的研究结果表明，rs3093030 与 CRC 的易感性无关，rs5498 在年龄≥61 岁的亚组中增加了 CRC 的风险。未来需要更大、种族同质性更高的人群来证实我们的结果。
