Evaluation of rs5498 and rs3093030 Polymorphisms in Chinese Patients with Colorectal Cancer.

Colorectal cancer (CRC) is a common cancer threatening human health. Intercellular adhesion molecule-1 (ICAM-1, CD54) displays a key role in carcinogenesis and previous studies have suggested that single-nucleotide polymorphisms (SNPs) are predicted to increase the risk of CRC. However, the relationship of SNPs with CRC susceptibility was controversial. We conducted a case-control study to clarify the association of SNPs (rs5498 and rs3093030) with the CRC risk. A total of 1003 CRC patients and 1303 controls were recruited to determine SNPs (rs5498 and rs3093030) by SNPscan method. In the case-control study, we found that rs5498 polymorphism did not influence CRC risk (AG vs. AA: adjusted  = 0.179; GG vs. AA: adjusted  = 0.281, AG+GG vs. AA: adjusted  = 0.398; GG vs. AA+AG: adjusted  = 0.153), and rs3093030 polymorphism did not influence CRC risk (CT vs. CC: adjusted  = 0.841; TT vs. CC: adjusted  = 0.175, CT+TT vs. CC: adjusted  = 0.574 and TT vs. CC+TT: adjusted  = 0.180). In a subgroup of age >61, rs5498 decreased the risk of CRC ( = 0.047). Multivariate analysis revealed that smoking ( = 0.002; odds ratio [OR]: 1.76, 95% confidence interval [CI]: 1.18-2.63), alcohol intake ( < 0.001; OR: 1.99, 95% CI: 1.31-3.05), and body mass index <24 ( < 0.001; OR: 1.55, 95% CI: 1.06-2.26) increased the risk of CRC. Our findings showed that rs3093030 was not correlated with the susceptibility of CRC, and rs5498 increased the risk of CRC in the subgroup of age ≥61. In the future, larger and ethnically homogeneous populations are needed to confirm our results.