Department of Neurology, Shanghai Sixth People's Hospital East Affiliated to Shanghai University of Medicine & Health Sciences, Shanghai, China.
Department of General Practice, Shanghai Pudong New District Dongming Community Healthcare Center, Shanghai, China.
Mol Genet Genomic Med. 2019 Jun;7(6):e643. doi: 10.1002/mgg3.643. Epub 2019 Apr 17.
Recently, associations between intercellular adhesion molecule-1 (ICAM-1) rs5498 polymorphism and ischemic stroke (IS) were investigated by several pilot studies, but with inconsistent results. In this study, a meta-analysis was performed to better assess the relationship between ICAM-1rs5498 polymorphism and IS.
PubMed, Medline, Embase, and CNKI were searched for eligible studies. We calculated odds ratios (ORs) and 95% confidence intervals (CIs) to evaluate associations between ICAM-1 rs5498 polymorphism and IS.
Totally 16 studies with 2,596 cases and 11,800 controls were analyzed. A significant association with IS was observed for rs5498 polymorphism in GG versus AA + AG (recessive model, p = 0.009, OR = 1.62, 95% CI 1.13-2.32, I = 76%) in overall population. Further subgroup analyses showed that rs5498 polymorphism was significantly associated with IS in Caucasians in AA versus AG + GG (dominant model, p = 0.03, OR = 0.52, 95% CI 0.29-0.95, I = 72%), GG versus AA + AG (recessive model, p < 0.0001, OR = 2.98, 95% CI 2.05-4.31, I = 19%), and A versus G (allele model, p = 0.005, OR = 0.50, 95% CI 0.31-0.81, I = 81%). However, no any positive findings were detected for Asians.
Our findings indicated that rs5498 polymorphism was significantly associated with individual susceptibility to IS in Caucasians, but not in Asians.
最近，几项初步研究探讨了细胞间黏附分子-1（ICAM-1）rs5498 多态性与缺血性脑卒中（IS）之间的关联，但结果不一致。本研究采用荟萃分析更好地评估了 ICAM-1 rs5498 多态性与 IS 之间的关系。
检索 PubMed、Medline、Embase 和中国知网（CNKI）以获取合格的研究。我们计算了比值比（OR）和 95%置信区间（CI）来评估 ICAM-1 rs5498 多态性与 IS 之间的关联。
共纳入了 16 项研究，包括 2596 例病例和 11800 例对照。在总体人群中，与 GG 相比，rs5498 多态性在 GG 与 AA+AG（隐性模型，p=0.009，OR=1.62，95%CI 1.13-2.32，I²=76%）中与 IS 显著相关。进一步的亚组分析显示，在高加索人群中，与 AA 相比，rs5498 多态性在 AA 与 AG+GG（显性模型，p=0.03，OR=0.52，95%CI 0.29-0.95，I²=72%）、GG 与 AA+AG（隐性模型，p<0.0001，OR=2.98，95%CI 2.05-4.31，I²=19%）和 A 与 G（等位基因模型，p=0.005，OR=0.50，95%CI 0.31-0.81，I²=81%）中与 IS 显著相关。然而，在亚洲人群中未发现任何阳性结果。
我们的研究结果表明，rs5498 多态性与高加索人群中 IS 的个体易感性显著相关，但与亚洲人群无关。
