莫洛尼鼠白血病病毒TB温度敏感致瘫突变体ts1包膜基因点突变的鉴定：神经毒力的分子决定因素
Identification of point mutations in the envelope gene of Moloney murine leukemia virus TB temperature-sensitive paralytogenic mutant ts1: molecular determinants for neurovirulence.
作者信息
Szurek P F, Yuen P H, Jerzy R, Wong P K
机构信息
University of Texas System Cancer Center, Science Park Research Division, Smithville 78957.
出版信息
J Virol. 1988 Jan;62(1):357-60. doi: 10.1128/JVI.62.1.357-360.1988.
Abstract
ts1, a temperature-sensitive mutant of Moloney murine leukemia virus TB, induces hind-limb paralysis in mice. The DNA of both the ts1 and Moloney murine leukemia virus TB env genes has been sequenced, and the encoded amino acid sequences have been deduced from the DNA sequences. Four amino acids in the ts1 envelope protein have been identified which may be responsible for the ts1 phenotype, which includes temperature sensitivity, nonprocessing of Pr80env, and neurovirulence.
摘要
ts1是莫洛尼鼠白血病病毒TB的一个温度敏感突变体，可诱导小鼠后肢麻痹。ts1和莫洛尼鼠白血病病毒TB env基因的DNA均已测序，并且已从DNA序列推导出编码的氨基酸序列。已确定ts1包膜蛋白中的四个氨基酸可能是ts1表型的原因，ts1表型包括温度敏感性、Pr80env未加工以及神经毒力。
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Identification of point mutations in the envelope gene of Moloney murine leukemia virus TB temperature-sensitive paralytogenic mutant ts1: molecular determinants for neurovirulence.莫洛尼鼠白血病病毒TB温度敏感致瘫突变体ts1包膜基因点突变的鉴定：神经毒力的分子决定因素
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