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1
Identification of point mutations in the envelope gene of Moloney murine leukemia virus TB temperature-sensitive paralytogenic mutant ts1: molecular determinants for neurovirulence.莫洛尼鼠白血病病毒TB温度敏感致瘫突变体ts1包膜基因点突变的鉴定：神经毒力的分子决定因素
J Virol. 1988 Jan;62(1):357-60. doi: 10.1128/JVI.62.1.357-360.1988.
2
A 1.6-kilobase-pair fragment in the genome of the ts1 mutant of Moloney murine leukemia virus TB that is associated with temperature sensitivity, nonprocessing of Pr80env, and paralytogenesis.莫洛尼鼠白血病病毒TB的ts1突变体基因组中的一个1.6千碱基对片段，其与温度敏感性、Pr80env的未加工以及麻痹发生相关。
J Virol. 1985 May;54(2):364-73. doi: 10.1128/JVI.54.2.364-373.1985.
3
The neurovirulent determinants of ts1, a paralytogenic mutant of Moloney murine leukemia virus TB, are localized in at least two functionally distinct regions of the genome.莫洛尼鼠白血病病毒TB的致瘫突变体ts1的神经毒力决定因素定位于基因组中至少两个功能不同的区域。
J Virol. 1986 Jul;59(1):59-65. doi: 10.1128/JVI.59.1.59-65.1986.
4
Site-directed mutagenesis of the codon for Ile-25 in gPr80env alters the neurovirulence of ts1, a mutant of Moloney murine leukemia virus TB.对gPr80env中异亮氨酸-25密码子进行定点诱变可改变莫洛尼氏鼠白血病病毒TB的突变体ts1的神经毒力。
J Virol. 1990 Nov;64(11):5241-9. doi: 10.1128/JVI.64.11.5241-5249.1990.
5
A Val-25-to-Ile substitution in the envelope precursor polyprotein, gPr80env, is responsible for the temperature sensitivity, inefficient processing of gPr80env, and neurovirulence of ts1, a mutant of Moloney murine leukemia virus TB.包膜前体多聚蛋白gPr80env中第25位缬氨酸到异亮氨酸的替换，导致了温度敏感性、gPr80env加工效率低下以及莫洛尼鼠白血病病毒TB的突变体ts1的神经毒性。
J Virol. 1990 Feb;64(2):467-75. doi: 10.1128/JVI.64.2.467-475.1990.
6
Molecular cloning of two paralytogenic, temperature-sensitive mutants, ts1 and ts7, and the parental wild-type Moloney murine leukemia virus.两种致麻痹性温度敏感突变体ts1和ts7以及亲本野生型莫洛尼鼠白血病病毒的分子克隆
J Virol. 1985 Apr;54(1):178-85. doi: 10.1128/JVI.54.1.178-185.1985.
7
Oligomerization and transport of the envelope protein of Moloney murine leukemia virus-TB and of ts1, a neurovirulent temperature-sensitive mutant of MoMuLV-TB.
Virology. 1991 Oct;184(2):687-94. doi: 10.1016/0042-6822(91)90438-h.
8
ts1, a Paralytogenic mutant of Moloney murine leukemia virus TB, has an enhanced ability to replicate in the central nervous system and primary nerve cell culture.ts1是莫洛尼鼠白血病病毒TB的一种致瘫突变体，在中枢神经系统和原代神经细胞培养物中具有增强的复制能力。
J Virol. 1985 Sep;55(3):760-7. doi: 10.1128/JVI.55.3.760-767.1985.
9
Construction and characterization of expression systems for the env gene of ts1, a mutant of Moloney murine leukemia virus-TB.
Virus Res. 1991 Mar;19(1):83-92. doi: 10.1016/0168-1702(91)90096-e.
10
Murine leukemia virus induced central nervous system diseases.鼠白血病病毒诱发的中枢神经系统疾病。
Leukemia. 1992;6 Suppl 3:161S-165S.

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Activation of transcription factor Nrf-2 and its downstream targets in response to moloney murine leukemia virus ts1-induced thiol depletion and oxidative stress in astrocytes.在星形胶质细胞中，转录因子Nrf-2及其下游靶点的激活是对莫洛尼鼠白血病病毒ts1诱导的硫醇耗竭和氧化应激的反应。
J Virol. 2004 Nov;78(21):11926-38. doi: 10.1128/JVI.78.21.11926-11938.2004.
6
Synthesis of virus-specific high-mobility DNA after temperature upshift of SC-1 cells chronically infected with moloney murine leukemia virus mutant ts1.用莫洛尼鼠白血病病毒突变体ts1长期感染的SC-1细胞温度上调后病毒特异性高迁移率DNA的合成
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Differential glycosylation of the Cas-Br-E env protein is associated with retrovirus-induced spongiform neurodegeneration.Cas-Br-E env蛋白的差异糖基化与逆转录病毒诱导的海绵状神经变性有关。
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Second-site changes affect viability of amphotropic/ecotropic chimeric enveloped murine leukemia viruses.第二位点变化影响双嗜性/亲嗜性嵌合包膜鼠白血病病毒的生存能力。
J Virol. 2000 Jan;74(2):899-913. doi: 10.1128/jvi.74.2.899-913.2000.
9
Genetic control and dynamics of the cellular immune response to the human T-cell leukaemia virus, HTLV-I.人类T细胞白血病病毒1型（HTLV-I）细胞免疫应答的遗传控制与动力学
Philos Trans R Soc Lond B Biol Sci. 1999 Apr 29;354(1384):691-700. doi: 10.1098/rstb.1999.0422.
10
Studies on the pathology, especially brain lesions, induced by R7, a spontaneous mutant of Moloney murine sarcoma virus 124.对莫洛尼氏鼠肉瘤病毒124的自发突变体R7所诱导的病理学，尤其是脑部病变的研究。
Am J Pathol. 1998 Jun;152(6):1509-20.

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Biological studies on a lymphoid-leukemia virus extracted from sarcoma 37. I. Origin and introductory investigations.从肉瘤37中提取的一种淋巴白血病病毒的生物学研究。I. 起源与初步研究。
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A fast replica plating technique for the isolation of post-integration mutants of the Moloney strain of murine leukaemia virus.一种用于分离莫洛尼鼠白血病病毒整合后突变体的快速影印培养技术。
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A group of temperature-sensitive mutants of Moloney leukemia virus which is defective in cleavage of env precursor polypeptide in infected cells also induces hind-limb paralysis in newborn CFW/D mice.一组莫洛尼白血病病毒的温度敏感突变体，其在感染细胞中对env前体多肽的切割存在缺陷，也会在新生CFW/D小鼠中诱发后肢麻痹。
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Isolation of paralysis-inducing murine leukemia viruses from Friend virus passaged in rats.从在大鼠体内传代的弗氏病毒中分离出致麻痹性小鼠白血病病毒。
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Deformed whiskers in mice infected with certain exogenous murine leukemia viruses.感染某些外源性鼠白血病病毒的小鼠出现变形的须毛。
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Nucleotide sequence of the Akv env gene.Akv包膜基因的核苷酸序列。
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Rapid, selective procedure for isolation of spontaneous temperature-sensitive mutants of Moloney leukemia virus.用于分离莫洛尼白血病病毒自发温度敏感突变体的快速、选择性程序。
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莫洛尼鼠白血病病毒TB温度敏感致瘫突变体ts1包膜基因点突变的鉴定：神经毒力的分子决定因素

Identification of point mutations in the envelope gene of Moloney murine leukemia virus TB temperature-sensitive paralytogenic mutant ts1: molecular determinants for neurovirulence.

作者信息

Szurek P F, Yuen P H, Jerzy R, Wong P K

机构信息

University of Texas System Cancer Center, Science Park Research Division, Smithville 78957.

出版信息

J Virol. 1988 Jan;62(1):357-60. doi: 10.1128/JVI.62.1.357-360.1988.

DOI:10.1128/JVI.62.1.357-360.1988
PMID:3334748
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC250539/
Abstract

ts1, a temperature-sensitive mutant of Moloney murine leukemia virus TB, induces hind-limb paralysis in mice. The DNA of both the ts1 and Moloney murine leukemia virus TB env genes has been sequenced, and the encoded amino acid sequences have been deduced from the DNA sequences. Four amino acids in the ts1 envelope protein have been identified which may be responsible for the ts1 phenotype, which includes temperature sensitivity, nonprocessing of Pr80env, and neurovirulence.

摘要

ts1是莫洛尼鼠白血病病毒TB的一个温度敏感突变体，可诱导小鼠后肢麻痹。ts1和莫洛尼鼠白血病病毒TB env基因的DNA均已测序，并且已从DNA序列推导出编码的氨基酸序列。已确定ts1包膜蛋白中的四个氨基酸可能是ts1表型的原因，ts1表型包括温度敏感性、Pr80env未加工以及神经毒力。