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1
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J Virol. 1983 Jan;45(1):1-9. doi: 10.1128/JVI.45.1.1-9.1983.
2
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3
Nucleotide sequence of the envelope gene of Gardner-Arnstein feline leukemia virus B reveals unique sequence homologies with a murine mink cell focus-forming virus.加德纳-阿恩斯坦猫白血病病毒B包膜基因的核苷酸序列显示出与鼠貂细胞集落形成病毒独特的序列同源性。
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Proc Natl Acad Sci U S A. 1983 Aug;80(15):4718-22. doi: 10.1073/pnas.80.15.4718.
5
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Molecular analysis of the envelope gene and long terminal repeat of Friend mink cell focus-inducing virus: implications for the functions of these sequences.弗氏貂细胞灶性诱导病毒包膜基因和长末端重复序列的分子分析：这些序列功能的启示
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Virological properties and nucleotide sequences of Cas-E-type endogenous ecotropic murine leukemia viruses in South Asian wild mice, Mus musculus castaneus.南亚野生小家鼠（Mus musculus castaneus）中Cas-E型内源性亲嗜性小鼠白血病病毒的病毒学特性及核苷酸序列
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本文引用的文献

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The spontaneous insertion of proteins into and across membranes: the helical hairpin hypothesis.蛋白质自发插入和穿过膜：螺旋发夹假说。
Cell. 1981 Feb;23(2):411-22. doi: 10.1016/0092-8674(81)90136-7.
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The function of the neuraminidase in membrane fusion induced by myxoviruses.神经氨酸酶在黏液病毒诱导的膜融合中的作用。
Virology. 1980 Dec;107(2):313-9. doi: 10.1016/0042-6822(80)90299-8.
3
Possible cell surface receptor for Friend murine leukemia virus isolated with viral envelope glycoprotein complexes.用病毒包膜糖蛋白复合物分离出的弗氏小鼠白血病病毒可能的细胞表面受体。
J Virol. 1980 Oct;36(1):291-4. doi: 10.1128/JVI.36.1.291-294.1980.
4
Specific inhibition of paramyxovirus and myxovirus replication by oligopeptides with amino acid sequences similar to those at the N-termini of the F1 or HA2 viral polypeptides.具有与F1或HA2病毒多肽N端氨基酸序列相似的氨基酸序列的寡肽对副粘病毒和粘液病毒复制的特异性抑制作用。
Virology. 1980 Aug;105(1):205-22. doi: 10.1016/0042-6822(80)90168-3.
5
Envelope polypeptides of Friend leukemia virus: purification and structural analysis.弗瑞德白血病病毒的包膜多肽：纯化与结构分析。
J Virol. 1980 Feb;33(2):597-605. doi: 10.1128/JVI.33.2.597-605.1980.
6
Speculations on RNA splicing.关于RNA剪接的推测。
Cell. 1981 Mar;23(3):643-6. doi: 10.1016/0092-8674(81)90425-6.
7
Separation procedure and sugar composition of oligosaccharides in the surface glycoprotein of Friend murine leukemia virus.弗氏小鼠白血病病毒表面糖蛋白中寡糖的分离程序及糖组成
Biochim Biophys Acta. 1982 Aug 27;717(3):491-501. doi: 10.1016/0304-4165(82)90293-8.
8
Glycoproteins of friend murine leukemia virus: separation and NH2-terminal amino acid sequences of gp69 and gp71.弗氏鼠白血病病毒的糖蛋白：gp69和gp71的分离及氨基末端氨基酸序列
J Virol. 1982 Apr;42(1):352-5. doi: 10.1128/JVI.42.1.352-355.1982.
9
Structure of retroviral RNAs produced by cell lines derived from spontaneous lymphomas of AKR mice.源自AKR小鼠自发性淋巴瘤的细胞系所产生的逆转录病毒RNA的结构
J Virol. 1982 Jan;41(1):18-29. doi: 10.1128/JVI.41.1.18-29.1982.
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Variation of influenza A, B, and C viruses.甲型、乙型和丙型流感病毒的变异
Science. 1982 Mar 19;215(4539):1468-74. doi: 10.1126/science.7038875.

弗氏鼠白血病病毒包膜基因的核苷酸序列。

Nucleotide sequence of the envelope gene of Friend murine leukemia virus.

作者信息

Koch W, Hunsmann G, Friedrich R

出版信息

J Virol. 1983 Jan;45(1):1-9. doi: 10.1128/JVI.45.1.1-9.1983.

DOI:10.1128/JVI.45.1.1-9.1983
PMID:6296423
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC256380/
Abstract

The envelope gene of the helper-independent, highly leukemogenic virus Friend murine leukemia virus was sequenced by using a molecular clone of a Friend murine leukemia provirus. The deduced amino acid sequences of the envelope proteins gp70 and p15env were homologous to the sequences of Moloney murine leukemia virus (86%) and Akv (76%). However, a stretch of about 40 amino acid residues near the middle of gp70 was dissimilar in Friend and Moloney murine leukemia viruses and Akv. In this type-specific region the gp70s of all three viruses contained more than 30% proline residues, giving this sequence a very rigid conformation. We suggest that this rigid and highly variable region of gp70 participates in infection by recognition of cell surface receptors and, in addition, might contribute to the different oncogenic spectra of murine leukemia viruses.

摘要

利用弗氏小鼠白血病前病毒的分子克隆对非依赖辅助病毒、高致白血病性的弗氏小鼠白血病病毒的包膜基因进行了测序。包膜蛋白gp70和p15env推导的氨基酸序列与莫洛尼小鼠白血病病毒（86%）和Akv（76%）的序列同源。然而，gp70中部附近约40个氨基酸残基的一段序列在弗氏和莫洛尼小鼠白血病病毒以及Akv中是不同的。在这个型特异性区域，所有三种病毒的gp70都含有超过30%的脯氨酸残基，使该序列具有非常刚性的构象。我们认为，gp70的这个刚性且高度可变的区域通过识别细胞表面受体参与感染，此外，可能有助于小鼠白血病病毒不同的致癌谱。