Lindemayer H, Santler R
Phlebologie. 1977 Apr-Jun;30(2):151-60.
The author reviews this classically held opinion, that the older sclerosants cause coagulation of the blood, while the newer sclerosants bring about an endothelial change which itself generates a thrombus. He attempts to analyse the clotting activity of the vein wall before and after the sclerosant injection. The first series of experiments gave the impression that the walls of veins subjected to a sclerosant injection had an increased fibrinolytic activity, in comparison with untreated veins. It was noted that this increase in activity was not permanent but transient. Further studies have shown that this interpretation may be premature, since there are several possible sources of error. A new series of experiments is in progress, and it would be premature to draw conclusions.
作者回顾了这种传统观点，即较老的硬化剂会导致血液凝固，而较新的硬化剂会引起内皮变化，进而形成血栓。他试图分析注射硬化剂前后静脉壁的凝血活性。第一系列实验给人的印象是，与未处理的静脉相比，接受硬化剂注射的静脉壁纤维蛋白溶解活性增加。值得注意的是，这种活性增加并非永久性的，而是短暂的。进一步的研究表明，由于存在几种可能的误差来源，这种解释可能为时过早。新的一系列实验正在进行中，现在得出结论还为时过早。
