Department of Pathology, Charles Nicolle Hospital, Tunis, Tunisia.
Department of Otorhinolaryngology, Charles Nicolle Hospital, Tunis, Tunisia.
Diagn Cytopathol. 2021 Apr;49(4):528-532. doi: 10.1002/dc.24682. Epub 2020 Dec 21.
This study aims to assess in our institutional experience the accuracy of fine needle aspiration cytology (FNAC) in the diagnosis of salivary gland masses (SGM) according to the Milan System for Reporting Salivary Gland Cytopathology (MSRSGC) and to an in-house system.
The study included 189 FNACs conducted between January 2011 and December 2019. The FNACs, classified according to the in-house system, were reclassified according the MSRSGC. Taking histopathology as gold standard, the measures of diagnostic accuracy of FNAC were determined for suspicion for malignancy (SFM) and malignant categories.
According to the in house system, FNAC diagnoses were classified as: 23 (12.2%) non-diagnostic (ND), 23 (12.2%) non-neoplastic (NN), 119 (62.9%) benign neoplasm (BN), 10 (5.2%) indefinite neoplasm (IN), 2 (1.1%) SFM, and 12 (6.4%) malignant (M). Based on the MSRSGC, there were 3 (1.5%) cases of atypia of undetermined significance (AUS) and 7 (3.7%) neoplasms of uncertain malignant potential (SUMP). The number of ND, NN, BN, SFM, and M cases were identical in the two systems. For both systems, the sensitivity, the specificity, the positive predictive value, the negative predictive value, and the accuracy for malignancy diagnosis were 77.8%, 100%, 100%, 97.6%, and 97.8%, respectively.
According to the MSRGC and to our in-house reporting system, FNAC is an accurate technique for the diagnosis of malignant salivary tumors with excellent specificity and good sensitivity. However, MSRGC has the advantage of standardization of salivary gland cytology reporting.
本研究旨在评估我们机构的经验，根据米兰唾液腺细胞病理学报告系统（MSRSGC）和内部系统，细针穿刺细胞学（FNAC）诊断唾液腺肿块（SGM）的准确性。
本研究纳入了 2011 年 1 月至 2019 年 12 月期间进行的 189 例 FNAC。根据内部系统对 FNAC 进行分类，并根据 MSRSGC 重新分类。以组织病理学为金标准，确定 FNAC 对恶性肿瘤可疑性（SFM）和恶性分类的诊断准确性。
根据内部系统，FNAC 诊断结果分类为：23 例（12.2%）非诊断性（ND），23 例（12.2%）非肿瘤性（NN），119 例（62.9%）良性肿瘤（BN），10 例（5.2%）不确定肿瘤（IN），2 例（1.1%）SFM，12 例（6.4%）恶性肿瘤（M）。根据 MSRSGC，有 3 例（1.5%）为不确定意义的非典型（AUS）和 7 例（3.7%）具有不确定恶性潜能的肿瘤（SUMP）。两种系统的 ND、NN、BN、SFM 和 M 病例数相同。对于两种系统，恶性肿瘤诊断的敏感性、特异性、阳性预测值、阴性预测值和准确性分别为 77.8%、100%、100%、97.6%和 97.8%。
根据 MSRGC 和我们的内部报告系统，FNAC 是一种准确的诊断恶性唾液腺肿瘤的技术，具有出色的特异性和良好的敏感性。然而，MSRGC 具有唾液腺细胞学报告标准化的优势。
