Department of Clinical Laboratory, People's Hospital of Deyang City, Deyang, China.
Microb Pathog. 2021 Jan;150:104703. doi: 10.1016/j.micpath.2020.104703. Epub 2020 Dec 24.
Contamination with the fungus Alternaria spp. is often considered to have originated from laboratory sources, which occasionally causes infection in immunocompromised patients, termed as phaeohyphomycosis. Here, we have reported a case of cutaneous alternariosis caused by Alternaria alternata. This diagnosis was based on microscopic examination and mycological culturing of patient's vesicular lesions, with the use of 5 molecular markers (namely, ITS, ATPase, Actin, rpb2, and tef1) for strain identification. We noted that Alternaria infection caused an increase in the serum level of (1-3)-β-D-glucan (BG) in the patients. To the best of our knowledge, no such finding has been reported in previously in the literature.
被链格孢菌属（Alternaria spp.）污染通常被认为来源于实验室，偶尔会导致免疫功能低下的患者感染，被称为暗色丝孢霉病。在此，我们报告了一例由链格孢菌（Alternaria alternata）引起的皮肤链格孢霉病。该诊断基于对患者水疱性病变的显微镜检查和真菌培养，并使用 5 个分子标记物（即 ITS、ATPase、肌动蛋白、rpb2 和 tef1）进行菌株鉴定。我们注意到，链格孢菌感染会导致患者血清（1-3）-β-D-葡聚糖（BG）水平升高。据我们所知，以前的文献中尚未有过这种发现。
