Colosi Ioana Alina, Crișan Maria, Țoc Dan Alexandru, Colosi Horațiu Alexandru, Georgiu Carmen, Sabou Marcela, Costache Carmen
Microbiology Department, Iuliu Hatieganu University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania.
Histology Department, Iuliu Hatieganu University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania.
J Fungi (Basel). 2023 Aug 11;9(8):839. doi: 10.3390/jof9080839.
is a melanic fungus capable of causing a wide variety of infections, some of which have lethal potential. It is a ubiquitous fungus and a well-known plant pathogen. Cutaneous infections with most often occur in the extremities of patients who perform conventional agriculture, thus being exposed to occupational hazards leading to the disruption of the skin barrier.
This paper presents the first case report from Romania of an itraconazole nonresponsive cutaneous alternariosis in a patient without any type of immunosuppression.
After an initial misdiagnosis regarding the etiology of the patient's skin infection, two successive punch biopsies, followed by mycologic examination, lead to the final diagnosis of cutaneous alternariosis. Treatment guided by antifungal susceptibility testing has been instituted, leading to the gradual healing of the patient's skin ulcerations.
The ability of to infect immunocompetent human hosts and to develop resistance to antifungal drugs highlight the importance of correctly diagnosing the etiology of skin ulcerations and instituting appropriate treatment guided by antifungal susceptibility testing whenever the suspicion of a fungal skin infection is plausible.
是一种黑色素真菌，能够引起多种感染，其中一些具有致命潜力。它是一种普遍存在的真菌，也是一种著名的植物病原体。皮肤感染最常发生在从事传统农业的患者的四肢，因此暴露于职业危害中，导致皮肤屏障破坏。
本文介绍了罗马尼亚首例在无任何免疫抑制类型的患者中对伊曲康唑无反应的皮肤链格孢菌病病例报告。
在对患者皮肤感染的病因进行初步误诊后，连续进行了两次穿刺活检，随后进行真菌学检查，最终诊断为皮肤链格孢菌病。已根据抗真菌药敏试验进行治疗，导致患者的皮肤溃疡逐渐愈合。
感染免疫功能正常的人类宿主并对抗真菌药物产生耐药性的能力凸显了正确诊断皮肤溃疡病因以及在怀疑有真菌性皮肤感染时根据抗真菌药敏试验进行适当治疗的重要性。
