Loughnan Alice, Gall Nicholas, James Stephen
King's College Hospital, Denmark Hill, Brixton, London SE5 9RS, United Kingdom of Great Britain and Northern Ireland.
Auton Neurosci. 2021 Mar;231:102762. doi: 10.1016/j.autneu.2020.102762. Epub 2020 Dec 16.
Postural Tachycardia Syndrome (PoTS) is a chronic condition often affecting multiple systems with varied presenting symptoms. Diagnosis is made by demonstrating cardiovascular criteria on standing along with clinical assessment. Cardiopulmonary exercise testing has been used to demonstrate and characterise the physiological response to exercise and the severity of the syndrome. Previous studies on exercise testing in these patients have focussed on cardiovascular changes alone. This series characterises the integrated cardiac and respiratory response to exercise seen with cardiopulmonary exercise testing. Our main findings show that peak oxygen uptake, work done and peak heart rate are significantly reduced from their respective predicted values in PoTS patients. However, despite this, most patients demonstrated a normal exercise capacity. Features of ventilatory inefficiency were also seen which suggest exercise capacity in these patients may be limited more by impaired ventilatory control such as dysfunctional breathing during exercise rather than by cardiovascular issues.
体位性心动过速综合征（PoTS）是一种慢性疾病，常影响多个系统，症状表现多样。通过站立时的心血管标准及临床评估进行诊断。心肺运动试验已被用于证明和描述对运动的生理反应以及该综合征的严重程度。此前关于这些患者运动试验的研究仅关注心血管变化。本系列研究描述了心肺运动试验中所见的运动时心脏和呼吸的综合反应。我们的主要发现表明，PoTS患者的峰值摄氧量、做功量和峰值心率与其各自的预测值相比显著降低。然而，尽管如此，大多数患者的运动能力仍属正常。还观察到通气效率低下的特征，这表明这些患者的运动能力可能更多地受到通气控制受损的限制，如运动时呼吸功能障碍，而非心血管问题。
