Department of Integrated Traditional Chinese and Western Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Institute of Integrated Traditional Chinese and Western Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Biomed Pharmacother. 2021 Feb;134:111129. doi: 10.1016/j.biopha.2020.111129. Epub 2020 Dec 24.
Ulcerative colitis (UC) is an inflammatory bowel disease with complex pathogenesis, which is affected by genetic factors, intestinal immune status and intestinal microbial homeostasis. Intestinal epithelial barrier defect is crucial to the development of UC. Berberine, extracted from Chinese medicine, can identify bitter taste receptor on intestinal Tuft cells and activate IL-25-ILC2-IL-13 immune pathway to impair damaged intestinal tract by promoting differentiation of intestinal stem cells, which might be a potential approach for the treatment of UC.
溃疡性结肠炎（UC）是一种具有复杂发病机制的炎症性肠病，受遗传因素、肠道免疫状态和肠道微生物稳态的影响。肠上皮屏障缺陷对 UC 的发展至关重要。小檗碱是从中药中提取的，可识别肠道 Tuft 细胞上的苦味受体，通过促进肠干细胞分化，激活 IL-25-ILC2-IL-13 免疫途径来损害受损的肠道，这可能是治疗 UC 的一种潜在方法。
