XR 注射用纳曲酮是否能像每日舌下给予丁丙诺啡-纳洛酮一样有效地预防复发？
Does XR injectable naltrexone prevent relapse as effectively as daily sublingual buprenorphine-naloxone?
机构信息
Mountain Area Health Education Center (MAHEC), Asheville, NC, USA.
Eshelman School of Pharmacy, University of North Carolina Health Sciences at MAHEC, Asheville, USA.
出版信息
J Fam Pract. 2020 Dec;69(10):E14-E15.
PMID:33348352
Abstract
YES. MONTHLY EXTENDED-RELEASE INJECTABLE NALTREXONE (XR-NTX) TREATS OPIOID USE DISORDER AS EFFECTIVELY AS DAILY SUBLINGUAL BUPRENORPHINE-NALOXONE (BUP-NX) WITHOUT CAUSING ANY INCREASE IN SERIOUS ADVERSE EVENTS OR FATAL OVERDOSES. (STRENGTH OF RECOMMENDATION: A, 2 GOOD-QUALITY RCTS).
摘要
是。每月注射一次纳曲酮（XR-NTX）长效制剂治疗阿片类药物使用障碍的效果与每日舌下含服丁丙诺啡-纳洛酮（BUP-NX）相当，且不会增加严重不良事件或致死性过量用药的风险。（推荐强度：A，2 项高质量 RCT）。
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