Haubner Frank, Rachinger Walter
HNO-Klinik, LMU Faculty of Medicine, München, Germany.
Neurochirurgie, LMU Faculty of Medicine, München, Germany.
Laryngorhinootologie. 2021 May;100(5):357-363. doi: 10.1055/a-1332-2002. Epub 2020 Dec 21.
Chordoma of the clivus belong to the rare tumors of the skull base. Due to their aggresive behaviour including intradural infiltration of neurovascular structures an interdisciplinary treatment is mandatory. This article gives an overview on current surgical concepts including the endoscopic approach as well as the postoperative radiotherapy. Novel diagnostic tools and molecular targets to optimize individual tumor therapy are discussed.
斜坡脊索瘤属于颅底罕见肿瘤。因其侵袭性生长行为，包括神经血管结构的硬膜内浸润，多学科治疗必不可少。本文概述了当前的手术理念，包括内镜手术方法以及术后放疗。还讨论了用于优化个体化肿瘤治疗的新型诊断工具和分子靶点。
