Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Centre, Tokyo, Japan.
Department of Health Data Science, Graduate School of Data Science, Yokohama, Japan.
Int J Cancer. 2021 Jun 1;148(11):2664-2673. doi: 10.1002/ijc.33450. Epub 2020 Dec 30.
Evidence of the association between dietary fiber intake and gastric cancer (GC) risk from prospective studies is limited. We examined the association between dietary fiber intake and GC risk in a large prospective study. A total of 91 946 eligible Japanese aged 45 to 74 years (42 773 men and 49 173 women) participated in a population-based cohort study (Japan Public Health Center-based prospective study). From a validated food frequency questionnaire with 138 food items, total and food source-specific dietary fiber intake was calculated as exposure. The hazard ratio (HR) and the 95% confidence interval (CI) of GC incidence according to quintile of dietary fiber intake were examined after adjusting for confounding factors. In total, 2228 GC cases (1559 men and 669 women) were observed during the 15.0 years follow-up. Total dietary fiber intake was not associated with GC risk; however, a marginally increased risk trend because of high HR in the highest quintile of total fiber intake was found in women (HR [95% CI] in Q5 vs Q1: 0.95 [0.79-1.14], P for trend .30 in men, HR [95% CI] 1.25 [0.98-1.61], P for trend .05 in women). Stratification by tumor location did not change the results. A marginal but not significant inverse trend was observed regarding cereal fiber intake and GC risk in men. Total dietary fiber intake was not associated with GC risk. Further studies are warranted to confirm this association.
前瞻性研究中膳食纤维摄入量与胃癌（GC）风险之间的关联证据有限。我们在一项大型前瞻性研究中研究了膳食纤维摄入量与 GC 风险之间的关联。共有 91946 名符合条件的 45 至 74 岁日本成年人（42773 名男性和 49173 名女性）参加了一项基于人群的队列研究（日本公共卫生中心前瞻性研究）。从经过验证的包含 138 种食物的食物频率问卷中，计算了总膳食纤维和食物来源特异性膳食纤维的摄入量作为暴露因素。调整混杂因素后，根据膳食纤维摄入量五分位数检查 GC 发病率的风险比（HR）和 95%置信区间（CI）。在 15.0 年的随访期间，共观察到 2228 例 GC 病例（1559 例男性和 669 例女性）。总膳食纤维摄入量与 GC 风险无关；然而，在女性中发现由于总纤维摄入量最高五分位数的 HR 较高而呈现出边缘增加的风险趋势（Q5 与 Q1 的 HR [95%CI]：0.95 [0.79-1.14]，趋势检验.30；男性 HR [95%CI]：1.25 [0.98-1.61]，趋势检验.05）。按肿瘤位置分层并没有改变结果。在男性中观察到谷物纤维摄入量与 GC 风险之间存在边际但不显著的负向趋势。总膳食纤维摄入量与 GC 风险无关。需要进一步的研究来证实这种关联。
