颈动脉体的胆碱能化学传递和麻醉药物效应。
Cholinergic Chemotransmission and Anesthetic Drug Effects at the Carotid Bodies.
机构信息
Department of Anesthesiology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.
出版信息
Molecules. 2020 Dec 17;25(24):5974. doi: 10.3390/molecules25245974.
Abstract
General anesthesia is obtained by administration of potent hypnotics, analgesics and muscle relaxants. Apart from their intended effects (loss of consciousness, pain relief and muscle relaxation), these agents profoundly affect the control of breathing, in part by an effect within the peripheral chemoreflex loop that originates at the carotid bodies. This review assesses the role of cholinergic chemotransmission in the peripheral chemoreflex loop and the mechanisms through which muscle relaxants and hypnotics interfere with peripheral chemosensitivity. Additionally, consequences for clinical practice are discussed.
摘要
全身麻醉是通过给予强效催眠药、镇痛药和肌肉松弛剂来实现的。除了它们的预期作用（意识丧失、止痛和肌肉松弛）外，这些药物还会深刻地影响呼吸的控制，部分原因是它们在起源于颈动脉体的外周化学感受反射环内的作用。这篇综述评估了胆碱能化学传递在外周化学感受反射环中的作用，以及肌肉松弛剂和催眠药干扰外周化学敏感性的机制。此外，还讨论了对临床实践的影响。
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