• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

对《关于洛佩斯 - 耶雷纳等人的〈大鼠中油橄榄苦素的吸收和肠道代谢概况〉2020年，，134》的评论的回复

Reply to "Comment on López-Yerena et al. 'Absorption and Intestinal Metabolic Profile of Oleocanthal in Rats' 2020, , 134".

作者信息

López-Yerena Anallely, Vallverdú-Queralt Anna, Mols Raf, Augustijns Patrick, Lamuela-Raventós Rosa M, Escribano-Ferrer Elvira

机构信息

Nutrition, Food Science and Gastronomy Department, XaRTA, Institute of Nutrition and Food Safety (INSA-UB), School of Pharmacy and Food Sciences, University of Barcelona, 08028 Barcelona, Spain.

CIBER Physiopathology of Obesity and Nutrition (CIBEROBN), Institute of Health Carlos III, 28029 Madrid, Spain.

出版信息

Pharmaceutics. 2020 Dec 17;12(12):1221. doi: 10.3390/pharmaceutics12121221.

DOI:10.3390/pharmaceutics12121221
PMID:33348608
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7765908/
Abstract

Recently, in February 2020, we published a study exploring the intestinal absorption and metabolism of oleocanthal (OLC) in rats. A single-pass intestinal perfusion technique (SPIP) was used, involving simultaneous sampling from the luminal perfusate and mesenteric blood. Later, comments on our published paper were released, requesting clarification of specific data. In this detailed reply, we hope to have addressed and clarified all the concerns of A. Kaddoumi and K. El Sayed and that the scientific community will benefit from both the study and the comments it has generated.

摘要

最近，在2020年2月，我们发表了一项关于探索油橄榄苦素（OLC）在大鼠体内肠道吸收和代谢的研究。采用了单通道肠道灌注技术（SPIP），包括同时从肠腔灌流液和肠系膜血液中取样。后来，对我们发表的论文发布了评论，要求对具体数据进行澄清。在这份详细的回复中，我们希望已经解决并澄清了A. 卡杜米和K. 埃尔·赛义德的所有担忧，并且科学界将从该研究及其引发的评论中受益。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10d1/7765908/638fd107fab6/pharmaceutics-12-01221-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10d1/7765908/a5edd255fc45/pharmaceutics-12-01221-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10d1/7765908/6bcf62d23e84/pharmaceutics-12-01221-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10d1/7765908/638fd107fab6/pharmaceutics-12-01221-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10d1/7765908/a5edd255fc45/pharmaceutics-12-01221-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10d1/7765908/6bcf62d23e84/pharmaceutics-12-01221-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10d1/7765908/638fd107fab6/pharmaceutics-12-01221-g003.jpg

相似文献

1
Reply to "Comment on López-Yerena et al. 'Absorption and Intestinal Metabolic Profile of Oleocanthal in Rats' 2020, , 134".对《关于洛佩斯 - 耶雷纳等人的〈大鼠中油橄榄苦素的吸收和肠道代谢概况〉2020年，，134》的评论的回复
Pharmaceutics. 2020 Dec 17;12(12):1221. doi: 10.3390/pharmaceutics12121221.
2
Absorption and Intestinal Metabolic Profile of Oleocanthal in Rats.大鼠中油橄榄苦素的吸收及肠道代谢概况
Pharmaceutics. 2020 Feb 5;12(2):134. doi: 10.3390/pharmaceutics12020134.
3
Comment on López-Yerena et al. "Absorption and Intestinal Metabolic Profile of Oleocanthal in Rats" 2020, , 134.对洛佩斯 - 耶雷纳等人所著《大鼠中油橄榄苦素的吸收及肠道代谢概况》的评论 2020年， ，134
Pharmaceutics. 2020 Jul 31;12(8):720. doi: 10.3390/pharmaceutics12080720.
4
Correction: López-Yerena, A., et al. "Absorption and Intestinal Metabolic Profile of Oleocanthal in Rats" 2020, , 134.更正：洛佩斯 - 耶雷纳，A.等人。“油橄榄苦素在大鼠体内的吸收及肠道代谢谱”，2020年，，134。
Pharmaceutics. 2020 Dec 17;12(12):1220. doi: 10.3390/pharmaceutics12121220.
5
Oleacein Intestinal Permeation and Metabolism in Rats Using an In Situ Perfusion Technique.采用原位灌注技术研究大鼠中油橄榄苦素的肠道渗透与代谢
Pharmaceutics. 2021 May 14;13(5):719. doi: 10.3390/pharmaceutics13050719.
6
Tissue Distribution of Oleocanthal and Its Metabolites after Oral Ingestion in Rats.大鼠口服摄入后油橄榄苦素及其代谢产物的组织分布
Antioxidants (Basel). 2021 Apr 27;10(5):688. doi: 10.3390/antiox10050688.
7
Health-promoting properties of oleocanthal and oleacein: Two secoiridoids from extra-virgin olive oil.油橄榄苦素和橄榄苦苷的促健康特性：特级初榨橄榄油中的两种次油橄榄苦苷。
Crit Rev Food Sci Nutr. 2020;60(15):2532-2548. doi: 10.1080/10408398.2019.1650715. Epub 2019 Aug 19.
8
Comparison of two approaches of intestinal absorption by puerarin.葛根素肠道吸收两种方法的比较。
J Pharmacol Toxicol Methods. 2014 Jul-Aug;70(1):6-11. doi: 10.1016/j.vascn.2014.03.170. Epub 2014 Mar 25.
9
New insights on the interaction mechanism between tau protein and oleocanthal, an extra-virgin olive-oil bioactive component.关于 Tau 蛋白与特级初榨橄榄油生物活性成分油橄榄苦苷相互作用机制的新见解。
Food Funct. 2011 Jul;2(7):423-8. doi: 10.1039/c1fo10064e. Epub 2011 Jul 7.
10
Intestinal absorption and intestinal lymphatic transport of sirolimus from self-microemulsifying drug delivery systems assessed using the single-pass intestinal perfusion (SPIP) technique and a chylomicron flow blocking approach: linear correlation with oral bioavailabilities in rats.采用肠灌流（SPIP）技术和乳糜微粒流阻断法评估自微乳给药系统中西罗莫司的肠吸收和肠淋巴转运：与大鼠口服生物利用度的线性相关性。
Eur J Pharm Sci. 2011 Jun 14;43(3):132-40. doi: 10.1016/j.ejps.2011.04.011. Epub 2011 Apr 20.

引用本文的文献

1
The Influence of Standard and Freeze-Dried Tofu on the Phenols and Quality of Virgin Olive Oil Used as an Immersion Medium.标准豆腐和冷冻干燥豆腐对用作浸渍介质的初榨橄榄油中酚类物质及品质的影响。
Molecules. 2025 Feb 3;30(3):672. doi: 10.3390/molecules30030672.
2
Metabolism and Bioavailability of Olive Bioactive Constituents Based on In Vitro, In Vivo and Human Studies.基于体外、体内和人体研究的橄榄生物活性成分的代谢和生物利用度。
Nutrients. 2022 Sep 13;14(18):3773. doi: 10.3390/nu14183773.
3
Oleacein Intestinal Permeation and Metabolism in Rats Using an In Situ Perfusion Technique.

本文引用的文献

1
Novel olive oil phenolic (-)-oleocanthal (+)-xylitol-based solid dispersion formulations with potent oral anti-breast cancer activities.新型橄榄油酚 (-)-橄榄苦苷 (+)-木糖醇固体分散体制剂具有强大的口服抗乳腺癌活性。
Int J Pharm. 2019 Oct 5;569:118596. doi: 10.1016/j.ijpharm.2019.118596. Epub 2019 Aug 5.
2
Characterization of bioactive and nutraceutical compounds occurring in olive oil processing wastes.橄榄加工废弃物中生物活性和营养化合物的特性。
Rapid Commun Mass Spectrom. 2019 Nov 15;33(21):1670-1681. doi: 10.1002/rcm.8514.
3
Novel liquid-liquid extraction and self-emulsion methods for simplified isolation of extra-virgin olive oil phenolics with emphasis on (-)-oleocanthal and its oral anti-breast cancer activity.
采用原位灌注技术研究大鼠中油橄榄苦素的肠道渗透与代谢
Pharmaceutics. 2021 May 14;13(5):719. doi: 10.3390/pharmaceutics13050719.
4
Tissue Distribution of Oleocanthal and Its Metabolites after Oral Ingestion in Rats.大鼠口服摄入后油橄榄苦素及其代谢产物的组织分布
Antioxidants (Basel). 2021 Apr 27;10(5):688. doi: 10.3390/antiox10050688.
5
Natural Bioactive Compounds Useful in Clinical Management of Metabolic Syndrome.天然生物活性化合物在代谢综合征临床治疗中的应用。
Nutrients. 2021 Feb 16;13(2):630. doi: 10.3390/nu13020630.
6
Spontaneous and Interaction of (-)-Oleocanthal with Glycine in Biological Fluids: Novel Pharmacokinetic Markers.（-）-油橄榄苦苷与生物体液中甘氨酸的自发相互作用：新型药代动力学标志物
ACS Pharmacol Transl Sci. 2021 Jan 5;4(1):179-192. doi: 10.1021/acsptsci.0c00166. eCollection 2021 Feb 12.
新型液-液萃取和自乳化方法简化了特级初榨橄榄油酚类物质的分离，重点是(-)-橄榄苦苷及其口服抗乳腺癌活性。
PLoS One. 2019 Apr 9;14(4):e0214798. doi: 10.1371/journal.pone.0214798. eCollection 2019.
4
[Changes of P-gp expression in rats’ small intestine and effects on uptake of levofloxacin after acute exposure to hypoxia].[急性缺氧暴露后大鼠小肠P-糖蛋白表达变化及其对左氧氟沙星摄取的影响]
Yao Xue Xue Bao. 2016 Sep;51(9):1412-6.
5
High Resolution Mass Spectrometric Analysis of Secoiridoids and Metabolites as Biomarkers of Acute Olive Oil Intake-An Approach to Study Interindividual Variability in Humans.利用高分辨质谱分析橄榄果次生物和代谢产物作为橄榄油急性摄入生物标志物—研究个体间差异的一种方法。
Mol Nutr Food Res. 2018 Jan;62(2). doi: 10.1002/mnfr.201700065. Epub 2017 Dec 19.
6
Regional Intestinal Permeability in Rats: A Comparison of Methods.大鼠区域性肠道通透性：方法比较。
Mol Pharm. 2017 Dec 4;14(12):4252-4261. doi: 10.1021/acs.molpharmaceut.7b00279. Epub 2017 Oct 5.
7
In Vivo Mechanisms of Intestinal Drug Absorption from Aprepitant Nanoformulations.体内阿瑞匹坦纳米制剂的肠道药物吸收机制。
Mol Pharm. 2017 Dec 4;14(12):4233-4242. doi: 10.1021/acs.molpharmaceut.7b00294. Epub 2017 Aug 10.
8
Quantitative method for determination of oleocanthal and oleacein in virgin olive oils by liquid chromatography-tandem mass spectrometry.采用液相色谱-串联质谱法测定特级初榨橄榄油中油酸酰胺和油橄榄苦苷的定量方法。
Talanta. 2017 Jan 1;162:24-31. doi: 10.1016/j.talanta.2016.09.056. Epub 2016 Sep 24.
9
Metabolic profile of naringenin in the stomach and colon using liquid chromatography/electrospray ionization linear ion trap quadrupole-Orbitrap-mass spectrometry (LC-ESI-LTQ-Orbitrap-MS) and LC-ESI-MS/MS.使用液相色谱/电喷雾电离线性离子阱四极杆-轨道阱质谱联用仪（LC-ESI-LTQ-Orbitrap-MS）和LC-ESI-MS/MS对柚皮素在胃和结肠中的代谢谱进行分析。
J Pharm Biomed Anal. 2016 Feb 20;120:38-45. doi: 10.1016/j.jpba.2015.10.040. Epub 2015 Dec 2.
10
Provisional in-silico biopharmaceutics classification (BCS) to guide oral drug product development.用于指导口服药物产品开发的临时计算机模拟生物药剂学分类系统（BCS）
Drug Des Devel Ther. 2014 Sep 24;8:1563-75. doi: 10.2147/DDDT.S68909. eCollection 2014.