López-Yerena Anallely, Vallverdú-Queralt Anna, Mols Raf, Augustijns Patrick, Lamuela-Raventós Rosa M, Escribano-Ferrer Elvira
Nutrition, Food Science and Gastronomy Department, XaRTA, Institute of Nutrition and Food Safety (INSA-UB), School of Pharmacy and Food Sciences, University of Barcelona, 08028 Barcelona, Spain.
CIBER Physiopathology of Obesity and Nutrition (CIBEROBN), Institute of Health Carlos III, 28029 Madrid, Spain.
Pharmaceutics. 2020 Dec 17;12(12):1221. doi: 10.3390/pharmaceutics12121221.
Recently, in February 2020, we published a study exploring the intestinal absorption and metabolism of oleocanthal (OLC) in rats. A single-pass intestinal perfusion technique (SPIP) was used, involving simultaneous sampling from the luminal perfusate and mesenteric blood. Later, comments on our published paper were released, requesting clarification of specific data. In this detailed reply, we hope to have addressed and clarified all the concerns of A. Kaddoumi and K. El Sayed and that the scientific community will benefit from both the study and the comments it has generated.
最近,在2020年2月,我们发表了一项关于探索油橄榄苦素(OLC)在大鼠体内肠道吸收和代谢的研究。采用了单通道肠道灌注技术(SPIP),包括同时从肠腔灌流液和肠系膜血液中取样。后来,对我们发表的论文发布了评论,要求对具体数据进行澄清。在这份详细的回复中,我们希望已经解决并澄清了A. 卡杜米和K. 埃尔·赛义德的所有担忧,并且科学界将从该研究及其引发的评论中受益。