Ziegeler Katharina, Eshed Iris, Diekhoff Torsten, Hermann Kay Geert
Department of Radiology, Charité-Universitätsmedizin Berlin, 10117 Berlin, Germany.
Department of Diagnostic Imaging, Sheba Medical Center, Tel Giborim Affiliated with the Sackler School of Medicine, Tel Aviv University, 52621 Tel Aviv, Israel.
J Clin Med. 2020 Dec 17;9(12):4074. doi: 10.3390/jcm9124074.
Autoinflammatory disorders are commonly characterized by seemingly unprovoked systemic inflammation mainly driven by cells and cytokines of the innate immune system. In many disorders on this spectrum, joint and bone involvement may be observed and imaging of these manifestations can provide essential diagnostic information. This review aimed to provide a comprehensive overview of the imaging characteristics for major diseases and disease groups on the autoinflammatory spectrum, including familial Mediterranean fever (FMF), Behçet disease (BD), crystal deposition diseases (including gout), adult-onset Still's disease (AoSD), and syndromatic synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO)/chronic recurrent multifocal osteomyelitis (CRMO). Herein, we discuss common and distinguishing imaging characteristics, phenotypical overlaps with related diseases, and promising fields of future research.
自身炎症性疾病通常表现为看似无端的全身炎症，主要由先天性免疫系统的细胞和细胞因子驱动。在这一谱系中的许多疾病中，可能会观察到关节和骨骼受累情况，对这些表现进行成像检查可为诊断提供重要信息。本综述旨在全面概述自身炎症谱系中主要疾病和疾病组的成像特征，包括家族性地中海热（FMF）、白塞病（BD）、晶体沉积病（包括痛风）、成人斯蒂尔病（AoSD）以及综合征性滑膜炎、痤疮、脓疱病、骨肥厚和骨炎（SAPHO）/慢性复发性多灶性骨髓炎（CRMO）。在此，我们讨论了常见和独特的成像特征、与相关疾病的表型重叠以及未来研究的有前景领域。
