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Chronic treatment with amitriptyline produces supersensitivity to nicotine.

作者信息

Dilsaver S C, Majchrzak M J, Alessi N E

机构信息

Department of Psychiatry, University of Michigan, Ann Arbor 48109.

出版信息

Biol Psychiatry. 1988 Jan 15;23(2):169-75. doi: 10.1016/0006-3223(88)90087-x.

DOI:10.1016/0006-3223(88)90087-x
PMID:3334885
Abstract

The authors used a thermoregulation paradigm to evaluate effects of amitriptyline (AMI) on the sensitivity of a nicotinic mechanism involved in the regulation of core temperature in rats. Treatment with this tricyclic was associated with a significant increase in the hypothermic response to nicotine. Supersensitivity persisted for a minimum of 7.5 days following the last dose of AMI, and a significant proportion of animals displayed increased sensitivity after 14.5 days of abstinence. Implications for the mechanism of action of AMI are highlighted.

摘要

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