Flemmer D D, Dilsaver S C
Department of Psychiatry, Ohio State University, Columbus 43210-1228.
Pharmacol Biochem Behav. 1989 Oct;34(2):261-3. doi: 10.1016/0091-3057(89)90309-2.
The routine handling of rats and the injection of saline is a stressor. The authors report that chronic twice daily injections of normal saline (1 ml/kg IP) for 14 days produced subsensitivity to the hypothermic effects of nicotine (1 ml/kg IP). The weekly injection of nicotine (1 mg/kg IP) does not produce this effect. The investigators propose that their findings reflect the effect of chronic stress on a nicotinic mechanism. Lithium, desipramine, fluoxetine, and amitriptyline also alter the thermic response to systemically injected nicotine. A nicotinic mechanism(s) may be involved in the neurobiology of chronic stress, actions of antidepressants, and conceivably the pathophysiology of depression.
对大鼠的常规处理及注射生理盐水是一种应激源。作者报告称，连续14天每天两次腹腔注射生理盐水（1毫升/千克）会导致对尼古丁（1毫升/千克腹腔注射）的降温作用产生亚敏感性。每周注射一次尼古丁（1毫克/千克腹腔注射）则不会产生这种效果。研究者提出，他们的发现反映了慢性应激对烟碱机制的影响。锂盐、去甲丙咪嗪、氟西汀和阿米替林也会改变对全身注射尼古丁的热反应。一种烟碱机制可能参与了慢性应激的神经生物学、抗抑郁药的作用，以及抑郁症的病理生理学。
