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用可溶解微针进行严重急性呼吸综合征冠状病毒2刺突蛋白受体结合域的皮内递送以诱导小鼠的体液和细胞反应。

Intradermal delivery of receptor-binding domain of SARS-CoV-2 spike protein with dissolvable microneedles to induce humoral and cellular responses in mice.

作者信息

Kuwentrai Chaiyaporn, Yu Jinming, Rong Li, Zhang Bao-Zhong, Hu Ye-Fan, Gong Hua-Rui, Dou Ying, Deng Jian, Huang Jian-Dong, Xu Chenjie

机构信息

School of Biomedical Sciences, Li Ka Shing Faculty of Medicine University of Hong Kong Hong Kong SAR China.

Department of Biomedical Engineering City University of Hong Kong Hong Kong SAR China.

出版信息

Bioeng Transl Med. 2020 Dec 12;6(1):e10202. doi: 10.1002/btm2.10202. eCollection 2021 Jan.

DOI:10.1002/btm2.10202
PMID:33349797
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7744900/
Abstract

The S1 subunit of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein contains an immunogenic receptor-binding domain (RBD), which is a promising candidate for the development of a potential vaccine. This study demonstrated that intradermal delivery of an S-RBD vaccine using a dissolvable microneedle skin patch can induce both significant B-cell and significant T-cell responses against S-RBD. Importantly, the outcomes were comparable to that of conventional bolus injection.

摘要

严重急性呼吸综合征冠状病毒2（SARS-CoV-2）刺突蛋白的S1亚基包含一个免疫原性受体结合结构域（RBD），这是开发潜在疫苗的一个有前景的候选物。本研究表明，使用可溶解微针皮肤贴片皮内递送S-RBD疫苗可诱导针对S-RBD的显著B细胞和显著T细胞反应。重要的是，结果与传统推注注射相当。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/463a/7823132/6d758a4fd918/BTM2-6-e10202-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/463a/7823132/d322e0095993/BTM2-6-e10202-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/463a/7823132/3784975700b5/BTM2-6-e10202-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/463a/7823132/e85dc789377e/BTM2-6-e10202-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/463a/7823132/369d1b37e423/BTM2-6-e10202-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/463a/7823132/6d758a4fd918/BTM2-6-e10202-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/463a/7823132/d322e0095993/BTM2-6-e10202-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/463a/7823132/3784975700b5/BTM2-6-e10202-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/463a/7823132/e85dc789377e/BTM2-6-e10202-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/463a/7823132/369d1b37e423/BTM2-6-e10202-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/463a/7823132/6d758a4fd918/BTM2-6-e10202-g005.jpg

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